Six months neoadjuvant imatinib improves resectability potential of gastric stromal tumors in Egyptian patients

International Journal of Surgery
Gamal M Saied, Ahmed M Kensarah

Abstract

Though recurrence is high, local excision is the preferred approach for dealing with gastric stromal tumors. Achieving negative margins is mandatory, sometimes requiring subtotal gastrectomy. Adjuvant imatinib is essential for advanced cases and prolonging survival; however, there is not enough data to recommend its use before surgery to increase resectability. The current study aims at investigating this concept in Egyptian patients. The study included 16 patients (13 males, 3 females, mean age 60 years) presenting with gastrointestinal stromal tumors (GISTs) who were candidates for emergency (n = 3) or elective (n = 13) surgery. Investigations included endoscopy (+biopsy), sonography, and computed tomography (CT). Patients were enrolled in two groups: A (n = 6: projected to planned surgery) and B (n = 7: harboring c-kit +ve tumors). Each B patient received imatinib (400 mg/day) for 6 months before surgery. Clinical and radiological evaluation was at day 100. The Chi-square test was used to check size changes, and p at <0.02535 was considered significant. All patients had abdominal discomfort, while 62.5% had epigastric pain, and 12.5% had hematemesis. Tumor sizes ranged from 8.4 to 20 cm 2/3 were located in the upper stomach....Continue Reading

References

Sep 1, 1983·The American Journal of Surgical Pathology·M T Mazur, H B Clark
Oct 13, 2001·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·K YokoiM Onda
Mar 1, 2002·The New England Journal of Medicine·Michelle A ElliottAyalew Tefferi
Aug 13, 2003·Southern Medical Journal·Obinna C IgwiloJanis Atkinson
Mar 27, 2004·ANZ Journal of Surgery·Chien-Liang LiuChin-Yuan Tzen
Jun 19, 2004·Anti-cancer Drugs·Daniela KatzNathan I Cherny
Oct 16, 2004·Journal of Pediatric Surgery·Megan M DurhamRichard R Ricketts
Oct 30, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerald AntochLutz S Freudenberg
Feb 17, 2005·World Journal of Surgical Oncology·Rajiv M MehtaVallath Balakrishnan
Mar 11, 2005·The New England Journal of Medicine·Dino VeneriEnzo Bonora
Jun 25, 2005·Journal of Clinical Pathology·M B LoughreyP M Waring
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Florian HallerLászló Füzesi
Jan 18, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P BucherPh Morel
Jul 17, 2008·World Journal of Surgical Oncology·Ruy J CruzLourdes A Cepeda
Feb 17, 2009·World Journal of Surgical Oncology·Edward AlabrabaPhilippe Taniere
Jul 25, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C MussiA Gronchi

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Citations

Feb 22, 2012·World Journal of Surgery·Shailesh V ShrikhandeK M Mohandas
Nov 10, 2011·Journal of Surgical Oncology·Megan V Caram, Scott M Schuetze
Aug 26, 2014·International Journal of Surgery·Hassan Al-ThaniAbdelHakem Tabeb

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