Six-Year Follow-Up of Fractional Flow Reserve-Guided Versus Angiography-Guided Coronary Artery Bypass Graft Surgery

Circulation. Cardiovascular Interventions
Stephane FournierEmanuele Barbato

Abstract

Fractional flow reserve (FFR)-guided coronary artery bypass graft (CABG) surgery has been associated with lower number of graft anastomoses, lower rate of on-pump surgery, and higher graft patency rate as compared with angiography-guided CABG surgery. However, no clinical benefit has been reported to date. Consecutive patients (n=627) treated by CABG between 2006 and 2010 were retrospectively included. In 198 patients, at least 1 stenosis was grafted according to FFR (FFR-guided group), whereas in 429 patients all stenoses were grafted based on angiography (angiography-guided group). The 2 coprimary end points were overall death or myocardial infarction and major adverse cardiovascular events (composite of overall death, myocardial infarction, and target vessel revascularization) up to 6-year follow-up. In the FFR-guided group, patients were significantly younger (66 [57-73] versus 70 [63-76]; P<0.001), more often male (82% versus 72%; P=0.008), and less often diabetic (21% versus 30%; P=0.023). Clinical follow-up (median, 85 [66-104] months) was analyzed in 396 patients after 1:1 propensity-score matching for these 3 variables. The rate of overall death or myocardial infarction was significantly lower in the FFR-guided (n=31 [...Continue Reading

References

Dec 8, 2004·Journal of the American College of Cardiology·Steven GoldmanUNKNOWN VA Cooperative Study Group #207/297/364
May 29, 2007·Journal of the American College of Cardiology·Nico H J PijlsBernard de Bruyne
Aug 29, 2012·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators
Aug 7, 2013·The Journal of Thoracic and Cardiovascular Surgery·T Bruce FergusonJohn M Cahill
Mar 20, 2014·European Heart Journal·Gabor TothBernard De Bruyne
Sep 2, 2014·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators

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Citations

Jul 12, 2018·Current Opinion in Cardiology·Bobby YanagawaJohn D Puskas
Jun 1, 2018·Circulation. Cardiovascular Interventions·Morton J Kern, Arnold H Seto
Jun 12, 2019·Radiology·Carole Dennie, Fraser D Rubens
Aug 17, 2019·European Heart Journal·Giuseppe Di GioiaEmanuele Barbato
Mar 14, 2020·Interactive Cardiovascular and Thoracic Surgery·Shruti JayakumarMarjan Jahangiri
Aug 30, 2019·Current Opinion in Cardiology·Etem CaliskanVolkmar Falk
Apr 1, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Torsten DoenstGloria Faerber
Jul 5, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gabor G TothEmanuele Barbato
Jun 7, 2019·European Heart Journal·Morton J Kern, Arnold H Seto
Jul 25, 2019·Journal of Clinical Medicine·Iginio ColaioriCarmine Morisco
May 16, 2019·Circulation. Cardiovascular Interventions·Stephane FournierEmanuele Barbato
Oct 18, 2020·Nature Reviews. Cardiology·Prakriti GabaGregg W Stone
Oct 1, 2018·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Om Prakash Yadava
Dec 15, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Francesco BrunoGaetano Maria De Ferrari
Sep 24, 2020·International Journal of Cardiology·Teruaki WadaTakashi Akasaka
Dec 12, 2020·JACC. Cardiovascular Imaging·Raymond Y Kwong, Y Chandrashekhar
Jan 24, 2021·Interactive Cardiovascular and Thoracic Surgery·Lukas StastnyNikolaos Bonaros
Sep 12, 2020·The American Journal of Cardiology·Khalid ChangalRajesh Gupta
Nov 3, 2020·International Journal of Cardiology·Vito D Bruno, Mustafa Zakkar
Jan 13, 2021·The Journal of Thoracic and Cardiovascular Surgery·Ho Young HwangKi-Bong Kim
Jun 13, 2020·The Annals of Thoracic Surgery·Paul A Kurlansky
Apr 11, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Stephane FournierEmanuele Barbato
Apr 21, 2021·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Jasmin H ShahinianDavid Glineur
Mar 31, 2020·JACC. Cardiovascular Interventions·William F Fearon, Jack H Boyd
Mar 31, 2020·JACC. Cardiovascular Interventions·Cristiano SpadaccioMario Gaudino
Jul 24, 2021·Journal of the American College of Cardiology·Patrick W SerruysSpencer B King Iii
Jul 8, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Gabor G TothEmanuele Barbato
Jul 10, 2021·Journal of the American College of Cardiology·Torsten DoenstMario Gaudino
Sep 7, 2021·Current Opinion in Cardiology·Katsuhiro HosoyamaYoshikatsu Saiki
Dec 17, 2020·The Journal of Thoracic and Cardiovascular Surgery·Torsten Doenst, Holger Sigusch

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