Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Jian-Wang LiLi-Gong Lu

Abstract

This work aims to study the roles and related mechanisms of six2 in 5-FU sensitivity of hepatocellular carcinoma (HCC) cells. KM-Plotter analysis showed that HCC patients with higher six2 expression levels had shorter overall survival. Six2 expression was higher in clinical HCC tissues than in normal tissues, and was negatively correlated with E-cadherin expression. Additionally, six2 overexpression decreased the sensitivity of HCC cells to 5-Fu, characterized as attenuating 5-FU-induced cell apoptosis and downregulation of cell viability, and promoted HCC cells stemness. Mechanistically, six2 overexpression repressed E-cadherin expression via stimulating promoter methylation of the E-cadherin. And E-cadherin overexpression rescued six2-induced decrease of 5-FU sensitivity and promotion on HCC cells stemness. Therefore, our results suggest that Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in HCC cells.

References

Jan 13, 2016·World Journal of Gastroenterology : WJG·Maridi AertsHendrik Reynaert
Aug 16, 2016·Biochemical and Biophysical Research Communications·Bingyu WangTao Xi
Sep 13, 2016·International Journal of Molecular Sciences·Jianing LiuGe Li
Nov 5, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mee SongSukjoon Yoon

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