Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development

Molecular and Cellular Biology
H OzakiK Kawakami

Abstract

Six4 is a member of the Six family genes, homologues of Drosophila melanogaster sine oculis. The gene is thought to be involved in neurogenesis, myogenesis, and development of other organs, based on its specific expression in certain neuronal cells of the developing embryo and in adult skeletal muscles. To elucidate the biological roles of Six4, we generated Six4-deficient mice by replacing the Six homologous region and homeobox by the beta-galactosidase gene. 5-Bromo-4-chloro-3-indolyl-beta-D-galactopyranoside staining of the heterozygous mutant embryos revealed expression of Six4 in cranial and dorsal root ganglia, somites, otic and nasal placodes, branchial arches, Rathke's pouch, apical ectodermal ridges of limb buds, and mesonephros. The expression pattern was similar to that of Six1 except at the early stage of embryonic day 8.5. Six4-deficient mice were born according to the Mendelian rule with normal gross appearance and were fertile. No hearing defects were detected. Six4-deficient embryos showed no morphological abnormalities, and the expression patterns of several molecular markers, e.g., myogenin and NeuroD3 (neurogenin1), were normal. Our results indicate that Six4 is not essential for mouse embryogenesis and sugge...Continue Reading

References

Aug 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J J Bieker, M Yazdani-Buicky
Nov 1, 1991·Science·R KühnW Müller
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A NagyJ C Roder
Apr 1, 1996·Genomics·C A BoucherK J Johnson
Sep 16, 1996·FEBS Letters·K KawakamiT Saito
Dec 1, 1996·Mechanisms of Development·G OliverP Gruss
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·J ToyO H Sundin
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·F SpitzP Maire
Dec 16, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V KalatzisC Petit
Mar 25, 1999·Genes & Development·F LoosliJ Wittbrodt
Jun 25, 1999·Mechanisms of Development·J Toy, O H Sundin
Aug 24, 1999·Cell·M E ZuberW A Harris
Jan 21, 2000·Cytogenetics and Cell Genetics·H OzakiK Kawakami
Apr 15, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J K LeeH Suh-Kim
May 10, 2000·Nature Genetics·T R KlesertS J Tapscott
Jul 6, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K KawakamiK Ikeda

❮ Previous
Next ❯

Citations

Jul 19, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pin-Xian Xu
Jul 30, 2010·Journal of Molecular Histology·Yuko SuzukiKiyoshi Kawakami
Sep 23, 2003·Developmental Biology·Bruce B Riley, Bryan T Phillips
Apr 3, 2012·The Journal of Clinical Investigation·Chu-An WangHeide L Ford
Jan 16, 2010·BMC Developmental Biology·Ricardo D ColettaHeide L Ford
Jul 20, 2010·BMC Genetics·Sumantra ChatterjeeThomas Lufkin
Oct 27, 2009·Future Oncology·Douglas S Micalizzi, Heide L Ford
Nov 10, 2015·Developmental Biology·Onur BirolAndrew K Groves
Aug 11, 2010·Experimental Cell Research·Hiroshi YajimaKiyoshi Kawakami
Jun 16, 2005·The FEBS Journal·Zen-Ichi AndoKiyoshi Kawakami
Oct 8, 2011·Journal of Anatomy·Yuko SuzukiKiyoshi Kawakami
Nov 20, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Karen M NeilsonSally A Moody
Sep 24, 2004·Current Opinion in Genetics & Development·Xiaoyan Zhu, Michael G Rosenfeld
Aug 30, 2006·Brain Research·Yoshiyuki KonishiKiyoshi Kawakami
Aug 16, 2005·Seminars in Cell & Developmental Biology·Charlotte A Berkes, Stephen J Tapscott
Dec 15, 2005·Zoology : Analysis of Complex Systems, ZACS·Gerhard Schlosser
Apr 24, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jinshu Xu, Pin-Xian Xu
Sep 3, 2011·Developmental Biology·Anne-Françoise RichardPascal Maire
Jan 25, 2012·Developmental Biology·Hajime OginoKunio Yasuda
Jul 2, 2003·Mechanisms of Development·Christine LaclefPascal Maire
Sep 17, 2011·Transcription·Tanja Francetic, Qiao Li
Aug 31, 2013·Developmental Cell·Yuka FujimotoRyuichi Nishinakamura
Nov 8, 2005·Developmental Biology·Katja Ahrens, Gerhard Schlosser
Jun 2, 2007·Developmental Biology·Aurore L'HonoréJacques Drouin
Mar 15, 2006·Developmental Biology·Dan ZouPin-Xian Xu
Jun 30, 2004·Developmental Biology·Gerhard Schlosser, Katja Ahrens
May 9, 2006·Developmental Biology·Gerhard Schlosser
Apr 6, 2006·Developmental Biology·Ivan B N ClarkAndrew P Jarman
Jun 5, 2012·Developmental Biology·Shigeru SatoKiyoshi Kawakami
May 26, 2016·Development, Growth & Differentiation·Hiroshi Yajima, Kiyoshi Kawakami
Jun 29, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Sally A MoodyFrancesca Pignoni
Mar 28, 2006·Current Topics in Developmental Biology·Andrew P Bailey, Andrea Streit
Jul 13, 2006·American Journal of Medical Genetics. Part a·Leisha D NolenRobyn V Jamieson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.