PMID: 18981505Nov 5, 2008

Size alters susceptibility of vectors to dengue virus infection and dissemination

The American Journal of Tropical Medicine and Hygiene
Barry W AltoL Philip Lounibos

Abstract

The size of arthropod vectors may affect their ability to transmit pathogens. Here we test the hypothesis that body size alters the susceptibility of Aedes aegypti and Aedes albopictus mosquitoes to dengue virus (DENV) infection and subsequent dissemination throughout the body of the mosquito. After feeding on blood containing known quantities of virus, smaller-sized females were significantly more likely to become infected and to disseminate virus than larger individuals. The effects of size were stronger for Ae. aegypti and independent of rearing conditions. Ae. albopictus was more susceptible to DENV infection and had higher virus titer in the body than Ae. aegypti, yet infected Ae. aegypti disseminated DENV more readily than infected Ae. albopictus. These results are consistent with the concept that Ae. aegypti is a more competent vector of DENV and emphasize the importance of body size in determining adult infection parameters.

Related Concepts

Dengue Fever
Arthropod Vectors
Insect Vectors
Reverse Transcriptase Polymerase Chain Reaction
Oligonucleotide Primers
Aedes aegypti
Aedes albopictus
Cloning Vectors
Tadpole
Culicidae