Size analysis of submicron particles by laser diffractometry--90% of the published measurements are false

International Journal of Pharmaceutics
Cornelia M Keck, Rainer H Müller

Abstract

The first part of this paper gives an easy and understandable introduction into modern laser diffractometry (LD). It explains why modern laser diffractometry is not only the simple detection of a diffraction pattern but a combination of two independent technologies, which is done to extend the measuring range down to several nanometers and incorrectly named LD measurement. In the second part the impact of the optical parameters on the result analysed was investigated. The results show, that changes in optical parameters change the particle size and the size distribution tremendously. For a trimodal mixture of latex particles, having a mean particle size of 845nm, mean particle sizes ranging from 284nm to up to 1.005microm were obtained due to the variation of the optical parameters. The obtained particle size distributions varied from monomodal, bimodal over trimodal to even tetramodal distributions. The results prove that the analysis of submicron particles is meaningless, if incorrect optical models are applied. Another hazard was found to be the use of the additional techniques for the extension to the submicron measuring range. Combining this technology with laser diffraction can fail to detect larger particles besides a sm...Continue Reading

Citations

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Apr 19, 2019·Molecular Pharmaceutics·Paulina JakubiakRubén Alvarez-Sánchez
Sep 4, 2021·Drug Delivery and Translational Research·Sabrina Wiemann, Cornelia M Keck

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