Size and shape-dependent cytotoxicity profile of gold nanoparticles for biomedical applications

Journal of Materials Science. Materials in Medicine
Anna WoźniakStefan Jurga

Abstract

Metallic nanoparticles, in particular gold nanoparticles (AuNPs), offer a wide spectrum of applications in biomedicine. A crucial issue is their cytotoxicity, which depends greatly on various factors, including morphology of nanoparticles. Because metallic nanoparticles have an effect on cell membrane integrity, their shape and size may affect the viability of cells, due to their different geometries as well as physical and chemical interactions with cell membranes. Variations in the size and shape of gold nanoparticles may indicate particular nanoparticle morphologies that provide strong cytotoxicity effects. Synthesis of different sized and shaped bare AuNPs was performed with spherical (~ 10 nm), nanoflowers (~ 370 nm), nanorods (~ 41 nm), nanoprisms (~ 160 nm) and nanostars (~ 240 nm) morphologies. These nanostructures were characterized and interacting with cancer (HeLa) and normal (HEK293T) cell lines and cell viability tests were performed by WST-1 tests and fluorescent live/dead cell imaging experiments. It was shown that various shapes and sizes of gold nanostructures may affect the viability of the cells. Gold nanospheres and nanorods proved to be more toxic than star, flower and prism gold nanostructures. This may be...Continue Reading

References

Apr 14, 2005·Journal of the American Chemical Society·Jill E MillstoneChad A Mirkin
Jun 19, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Hirak K PatraAnjan Kr Dasgupta
Oct 25, 2007·Clinical Pharmacology and Therapeutics·L ZhangO C Farokhzad
Dec 8, 2007·Arhiv za higijenu rada i toksikologiju·Damjana Drobne
Jan 31, 2008·Chemical Reviews·Matthew E StewartRalph G Nuzzo
Sep 2, 2008·Nature Reviews. Drug Discovery·Mark E DavisDong M Shin
Sep 25, 2009·Journal of the Royal Society, Interface·Xiue JiangG Ulrich Nienhaus
May 8, 2010·Physical Chemistry Chemical Physics : PCCP·Ewa KowalskaBunsho Ohtani
Aug 31, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Daizy Philip
Oct 26, 2012·Nanotechnology·Julien R G NavarroStephane Parola
Mar 23, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Patrick J StraneyJill E Millstone
Jul 28, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Julien R G NavarroStephane Parola
Mar 5, 2014·International Journal of Nanomedicine·Satomi OnoueHak-Kim Chan
May 3, 2014·Nanomedicine·Hye Sung Kim, Hyuk Sang Yoo
Jun 1, 2014·Nanomedicine·Alfredo AmbrosoneClaudia Tortiglione
Dec 17, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Giuseppa VisalliAngela Di Pietro
Mar 21, 2015·Environmental Toxicology and Pharmacology·Ying TangYongji Yang

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Citations

Nov 27, 2019·Nanotechnology·Francisca Villanueva-FloresLaura A Palomares
Aug 8, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jesuthankaraj Grace NirmalaManu Lopus
Dec 14, 2018·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Cecilia Fernández-PonceRocío Litrán
Oct 17, 2019·Journal of Nanobiotechnology·J DepciuchM Parlinska-Wojtan
Feb 18, 2020·Nanomedicine·Dana M SamhadanehUrsula Stochaj
Jun 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sin-Yeang TeowKamyar Shameli
Apr 25, 2019·Nano Convergence·Melanie A Fuller, Ingo Köper
Oct 3, 2019·Biosensors·Bartosz F GrześkowiakRyszard Słomski
Aug 19, 2020·Pharmaceuticals·Clara GerosaDaniela Fanni
Oct 24, 2019·Current Topics in Medicinal Chemistry·Huiqiong JiaZhi Ruan
Jun 9, 2020·Frontiers in Immunology·Edward B ThorpXunrong Luo
Oct 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michele S MajoumouoMervin Meyer
Dec 19, 2020·Nanotoxicology·Ceyda Oksel KarakusDavid A Winkler
Dec 31, 2020·International Journal of Molecular Sciences·Marika MusielakWiktoria Suchorska
Nov 6, 2020·Regenerative Biomaterials·Giovanna CalabreseSabrina Conoci
Mar 18, 2021·International Journal of Nanomedicine·Ewelina PiktelRobert Bucki
May 1, 2021·Frontiers in Bioengineering and Biotechnology·Qinyue GaoDongqing Wang
Jun 3, 2021·International Journal of Molecular Sciences·Daniil V KladkoArtur Y Prilepskii
May 30, 2021·Life Sciences·Abouzar BabaeiAfagh Moattari
Jun 26, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Nour K YounisAli H Eid
Sep 22, 2021·Nanotechnology·Isabela Barreto da Costa Januário MeirelesEdésia Martins Barros de Sousa
Nov 7, 2021·Small·Miriam FilippiRobert K Katzschmann

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