Size and shape of commercially available polyethylene particles for in-vitro and in-vivo-experiments

Zeitschrift für Orthopädie und ihre Grenzgebiete
Marius von KnochMarkus A Wimmer

Abstract

The longevity of total hip arthroplasty is sometimes limited by osteolysis and aseptic loosening. Aseptic loosening may be caused by the biologic reaction to polyethylene wear particles. Particles of less than 1 micro m diameter are of particular importance. These particles are not easily available for experimental use. We performed a morphologic analysis of commercially available, very small polyethylene particles (Ceridust(R)) in order to determine the specific size distribution. We measured 1 978 particles. Size analysis was performed using an electron microscope. Particle size was described as the equivalent circle diameter (ECD). Particle morphology was described as feret ratio. In addition, Ceridust(R) particles were compared to different particles stemming from a hip simulator experiment. More than 35 % of the particles were less than 1 micro m in size. The particle size was 1.75 micro m +/- 1.43 micro m (median 1.42 micro m). The minimum was 0.06 micro m, the maximum was 11.06 micro m. The feret ratio was 0.58 +/- 0.17 (median 0.63). The minimum was 0.07, the maximum was 0.93. The majority of Ceridust(R) particles had a rough surface. Compared to polyethylene particles stemming from a hip simulator experiment, Ceridust(...Continue Reading

Citations

Apr 3, 2007·Calcified Tissue International·C WedemeyerG Saxler
Aug 17, 2011·BMC Musculoskeletal Disorders·Max D KautherChristian Wedemeyer
Jul 12, 2005·Biomedizinische Technik. Biomedical Engineering·F von KnochM von Knoch
Aug 14, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Max D KautherChristian Wedemeyer
Nov 20, 2013·Journal of Materials Science. Materials in Medicine·A C PaulusS Utzschneider
Oct 24, 2007·Calcified Tissue International·Christian WedemeyerGuido Saxler
Nov 6, 2010·Journal of Orthopaedic Surgery and Research·Jie XuUNKNOWN Study was performed at the University of Duisburg - Essen, Germany
May 5, 2005·Biomaterials·Fabian von KnochMarius von Knoch
Aug 10, 2005·Journal of Biomedical Materials Research. Part a·Fabian von KnochMarius von Knoch
Dec 29, 2004·Biomaterials·Christian WedemeyerMarius von Knoch

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