Size and Volumetric Growth Kinetics of Renal Masses in Patients With Renal Cell Carcinoma

Urology
Sin Woo LeeSeong Il Seo

Abstract

To examine radiological growth patterns as an indicator of renal tumor aggressiveness, we studied about the growth kinetics of small renal mass (SRM, ≤4 cm) and possible associated factors for high Fuhrman nuclear grade (≥3). From January 1999 to May 2013, 112 cases (111 patients) diagnosed as renal cell carcinoma after surgical treatment were reviewed retrospectively. Patients who had at least two preoperative contrast-enhanced computed tomography scans more than 6 months apart were included. The mean age was 59 years and mean computed tomography follow-up duration was 20 months. Median tumor size and tumor volume at diagnosis were 1.45 cm and 1.80 cm(3), respectively. Median linear growth rate (LGR) was 0.28 cm/year. Median volumetric growth rate was 0.75 cm(3)/year and median volume doubling time was 1.41 years. Tumor growth rate was not different to histologic type (P = .271). High LGR was a significant factor associated with high Fuhrman grade in multivariate analysis (odds ratio 3.877, 95% confidence interval 1.715-8.765). Volumetric growth rate (P <.001) and volume doubling time (P = .004) were positive correlation with initial mass size, but not LGR (P = .764). In our growth kinetics study, generally small renal mass gr...Continue Reading

References

Oct 1, 1982·The American Journal of Surgical Pathology·S A FuhrmanC Limas
May 11, 1999·JAMA : the Journal of the American Medical Association·W H ChowJ F Fraumeni
Jul 26, 2005·Radiology·Gary M Israel, Morton A Bosniak
May 20, 2009·The Journal of Urology·R Houston ThompsonPaul Russo
Aug 18, 2009·The Journal of Urology·Steven C CampbellUNKNOWN Practice Guidelines Committee of the American Urological Association
Jul 17, 2010·European Urology·Börje LjungbergUNKNOWN European Association of Urology Guideline Group
Apr 12, 2011·European Urology·Michael A S JewettAntonio Finelli
Nov 23, 2011·Journal of Cancer Research and Clinical Oncology·Xue-Song LiZhi-Song He
Apr 14, 2012·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyu-Won JungJin-Soo Lee
Jan 31, 2013·International Urology and Nephrology·Eugenio BrunocillaGiuseppe Martorana
Mar 1, 2014·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Michael OrganRicardo A Rendon
Mar 20, 2014·The Journal of Urology·Reza MehrazinRobert G Uzzo
Jan 30, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Hye Won LeeHwang Gyun Jeon

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