Size control of the Drosophila hematopoietic niche by bone morphogenetic protein signaling reveals parallels with mammals.

Proceedings of the National Academy of Sciences of the United States of America
Delphine PennetierMichèle Crozatier

Abstract

The Drosophila melanogaster larval hematopoietic organ, the lymph gland, is a model to study in vivo the function of the hematopoietic niche. A small cluster of cells in the lymph gland, the posterior signaling center (PSC), maintains the balance between hematopoietic progenitors (prohemocytes) and their differentiation into specialized blood cells (hemocytes). Here, we show that Decapentaplegic/bone morphogenetic protein (Dpp/BMP) signaling activity in PSC cells controls niche size. In the absence of BMP signaling, the number of PSC cells increases. Correlatively, no hemocytes differentiate. Controlling PSC size is, thus, essential for normal blood cell homeostasis. Activation of BMP signaling in the PSC requires expression of the Dally-like heparan-sulfate proteoglycan, under the control of the Collier/early B-cell factor (EBF) transcription factor. A Dpp > dpp autoregulatory loop maintains BMP signaling, which limits PSC cell proliferation by repressing the protooncogene dmyc. Dpp antagonizes activity of wingless (Wg)/Wnt signaling, which positively regulates the number of PSC cells via the control of Dmyc expression. Together, our data show that Collier controls hemocyte homeostasis via coordinate regulation of PSC cell num...Continue Reading

References

Feb 13, 2001·Developmental Biology·R LanotM Meister
Feb 6, 2003·Genes & Development·Tim LebestkyUtpal Banerjee
Mar 7, 2003·Development·Momoko FujiseHiroshi Nakato
Oct 24, 2003·Nature·L M CalviD T Scadden
Mar 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Molly Duman-ScheelWei Du
Apr 29, 2005·Development·Seung-Hye JungUtpal Banerjee
Jun 24, 2006·The Journal of Biological Chemistry·Michael D Gordon, Roel Nusse
Feb 15, 2007·PLoS Biology·Magnus BaumgardtStefan Thor
May 23, 2007·Journal of Cell Science·Catherine A Kirkpatrick, Scott B Selleck
Aug 19, 2007·Nature Reviews. Genetics·Markus Affolter, Konrad Basler
Feb 1, 2008·Developmental Biology·Michèle Crozatier, Alain Vincent
Mar 8, 2008·Nature Reviews. Immunology·Mark J Kiel, Sean J Morrison
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joel L FrandsenStuart J Newfeld
May 23, 2009·Developmental Cell·Sergey A SinenkoUtpal Banerjee
Jun 6, 2009·Cell Stem Cell·Russell W Garrett, Stephen G Emerson
Sep 18, 2009·Blood·Devorah C GoldmanWilliam H Fleming
Dec 17, 2009·Nature Structural & Molecular Biology·Alexander WeissMarkus Affolter
Dec 22, 2009·Development·Svetlana Minakhina, Ruth Steward
Jan 9, 2010·Development·Jonathan EnriquezAlain Vincent
Jan 30, 2010·Science·Linheng Li, Hans Clevers
Feb 26, 2010·Nature Reviews. Immunology·Andreas TrumppAnne Wilson
Jul 14, 2010·Nature Cell Biology·Judith L Leatherman, Stephen Dinardo
Aug 17, 2010·Developmental Biology·Joanna KrzemienAlain Vincent
Aug 17, 2010·The International Journal of Developmental Biology·Joanna KrzemienAlain Vincent
Jun 15, 2011·Disease Models & Mechanisms·Michèle Crozatier, Alain Vincent
Aug 25, 2011·Current Opinion in Genetics & Development·Shuyi ChenTing Xie

❮ Previous
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Citations

Sep 18, 2012·Biochimica Et Biophysica Acta·Paul Faustin Seke EtetArmel Hervé Nwabo Kamdje
Mar 2, 2016·Fly·Billel BenmimounLucas Waltzer
Dec 24, 2015·Mediators of Inflammation·Annette H Schmitt-GraeffRobert Zeiser
Feb 18, 2015·The FEBS Journal·Isabella Vlisidou, Will Wood
Jun 20, 2014·Experimental Hematology·Katrina S Gold, Katja Brückner
Jul 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Billel BenmimounLucas Waltzer
Sep 27, 2013·JAK-STAT·Ismaël Morin-PoulardMichèle Crozatier
Oct 2, 2012·Fly·Kalpana Makhijani, Katja Brückner
Nov 26, 2013·Cell·Jiwon ShimUtpal Banerjee
May 13, 2014·Seminars in Cell & Developmental Biology·Fisun HamaratogluGeorge Pyrowolakis
Oct 5, 2014·Biochemical and Biophysical Research Communications·Victoria LamRobert A Schulz
Apr 28, 2016·Seminars in Immunology·Katrina S Gold, Katja Brückner
Jul 28, 2016·FEBS Letters·Manon LetourneauMichèle Crozatier
Nov 14, 2016·Developmental Biology·Caroline BarilMarc Therrien
May 20, 2016·Nature Communications·Ismaël Morin-PoulardMichèle Crozatier
Mar 21, 2019·Development·Rohan J Khadilkar, Guy Tanentzapf
Mar 8, 2019·Genes·Gergely I B VargaViktor Honti
Jan 30, 2014·Médecine sciences : M/S·Ismaël Morin-PoulardMichèle Crozatier
Feb 9, 2019·Genetics·Utpal BanerjeeCarrie M Spratford
Mar 28, 2019·Frontiers in Cell and Developmental Biology·Christopher B Mahony, Julien Y Bertrand
Jul 30, 2020·International Journal of Molecular Sciences·Wenwen LanYing Su
Nov 28, 2019·Glycoconjugate Journal·Shoko Nishihara
Mar 18, 2019·Biochemistry. Biokhimii︠a︡·T I FetisovG A Belitsky
Jun 9, 2020·Frontiers in Cell and Developmental Biology·Fangzhou LuoLi Hua Jin
Jan 26, 2021·Journal of Cellular Physiology·Dushyant Kumar GautamIndira Paddibhatla
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Anjeli MaseKatja Brückner

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