Aug 1, 2012

Size-dependent antimicrobial properties of CuO nanoparticles against Gram-positive and -negative bacterial strains

International Journal of Nanomedicine
Ameer AzamAdnan Memic

Abstract

CuO is one of the most important transition metal oxides due to its captivating properties. It is used in various technological applications such as high critical temperature superconductors, gas sensors, in photoconductive applications, and so on. Recently, it has been used as an antimicrobial agent against various bacterial species. Here we synthesized different sized CuO nanoparticles and explored the size-dependent antibacterial activity of each CuO nanoparticles preparation. CuO nanoparticles were synthesized using a gel combustion method. In this approach, cupric nitrate trihydrate and citric acid were dissolved in distilled water with a molar ratio of 1:1. The resulting solution was stirred at 100°C, until gel was formed. The gel was allowed to burn at 200°C to obtain amorphous powder, which was further annealed at different temperatures to obtain different size CuO nanoparticles. We then tested the antibacterial properties using well diffusion, minimum inhibitory concentration, and minimum bactericidal concentration methods. XRD spectra confirmed the formation of single phase CuO nanoparticles. Crystallite size was found to increase with an increase in annealing temperature due to atomic diffusion. A minimum crystallite...Continue Reading

  • References8
  • Citations49

References

Mentioned in this Paper

Gram-Positive Bacteria
Copper dioxide (CuO2)
Structure-Activity Relationship
Citricum acidum, citric acid, homeopathic preparation
Distilled water
Particle Size
Spectroscopy, Fourier Transform Infrared
Copper
Gram-Negative Bacteria
X-Ray Diffraction

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