Size dependent cellular uptake, in vivo fate and light-heat conversion efficiency of gold nanoshells on silica nanorattles

Nanoscale
Huiyu LiuFangqiong Tang

Abstract

Despite advances in photothermal therapy of gold nanoshells, reliable evaluations of their size dependence on the relative biological effects are needed. We report the size effects of PEGylated gold nanoshells on silica nanorattles (pGSNs) on their cellular uptake, in vivo fate and light-heat conversion efficiency in this study. The results indicate that smaller pGSNs have enhanced cellular uptake by the MCF-7 cells. For in vivo biodistribution study, pGSNs of different particle sizes (84-315 nm) distribute mainly in the liver and spleen in MCF-7 tumor-bearing BALB/c nude mice. Smaller pGSNs have a longer blood-circulation lifetime and higher light-heat conversion efficiency both in vitro and in vivo compared with larger ones. All three sizes of pGSNs can be excreted from the mice body at a slow rate and do not cause tissue toxicity after intravenous injection at a dosage of 20 mg kg(-1) for three times. The data support the feasibility of optimizing the therapeutic process for photothermal cell killing by plasmonic gold nanoshells.

References

Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
Oct 26, 2005·Drug Discovery Today·Francesco M Veronese, Gianfranco Pasut
Feb 14, 2006·The Journal of Physical Chemistry. B·Min HuGregory V Hartland
Apr 13, 2006·Nano Letters·B Devika ChithraniWarren C W Chan
Jun 15, 2006·The Journal of Physical Chemistry. B·Nadine HarrisMichael B Cortie
Aug 4, 2007·Lasers in Medical Science·Xiaohua HuangMostafa A El-Sayed
Mar 11, 2010·Breast Cancer Research and Treatment·Laura B CarpinRebekah A Drezek
Jul 21, 2010·Nanoscale·Wolfgang Schärtl

❮ Previous
Next ❯

Citations

May 21, 2013·ACS Applied Materials & Interfaces·Xuandong WangFangqiong Tang
Nov 28, 2013·Chemical Reviews·Lev A Dykman, Nikolai G Khlebtsov
Apr 23, 2013·The Journal of Pharmacy and Pharmacology·Mohammad Zaki AhmadFarhan Jalees Ahmad
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei ChenRainer Haag
Jun 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan WeiXuliang Deng
Mar 8, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Man AoYazhou Ao
Nov 13, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Wen LiYuanyan Liu
Dec 17, 2019·Current Pharmaceutical Design·Weizhen XuGuangwei Wang
Aug 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ji LiuEtienne Duguet
Oct 30, 2020·International Journal of Nanomedicine·Wisam Nabeel IbrahimAbd Almonem Doolaanea
Apr 21, 2016·Bioconjugate Chemistry·Min ZhouChun Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.