Abstract
Physiochemical changes, including size, are known to affect gold nanoparticle cellular internalization and treatment efficacy. Here, we report the effect of four sizes of cystine/citric acid-coated confeito-like gold nanoparticles (confeito-AuNPs) (30, 60, 80 and 100nm) on cellular uptake, intracellular localization and photothermal anticancer treatment efficiency in MDA-MB231 breast cancer cells. Cellular uptake is size dependent with the smallest size of confeito-AuNPs (30nm) having the highest cellular internalization via clathrin- and caveolae-mediated endocytosis. However, the other three sizes (60, 80 and 100nm) utilize clathrin-mediated endocytosis for cellular uptake. The intracellular localization of confeito-AuNPs is related to their endocytosis mechanism, where all sizes of confeito-AuNPs were localized highly in the lysosome and mitochondria, while confeito-AuNPs (30nm) gave the highest localization in the endoplasmic reticulum. Similarly, a size-dependent trend was also observed in in vitro photothermal treatment experiments, with the smallest confeito-AuNPs (30nm) giving the highest cell killing rate, whereas the largest size of confeito-AuNPs (100nm) displayed the lowest photothermal efficacy. Its desirable physi...Continue Reading
Citations
Jun 7, 2019·Nanomedicine·Yuanyuan GengWei Jiang
Feb 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fengren WuBangshang Zhu
May 20, 2020·International Journal of Nanomedicine·Behzad NasseriThomas J Webster
Jul 4, 2020·Nanotechnology·Ankita MishraAshok Kumar
Jul 3, 2019·Frontiers in Oncology·Suliman KhanHongwei Hou
Mar 21, 2020·Frontiers in Bioengineering and Biotechnology·Nora BloiseLivia Visai
Jun 9, 2018·Nanomaterials·Ya-Hui HanAi-Zheng Chen
Jul 31, 2018·Frontiers in Pharmacology·Ting ChenGuimiao Lin
Mar 27, 2020·International Journal of Nanomedicine·Somayeh KarimiReza Sheikhnejad
Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui Shan LiewMay Lee Low
Jun 5, 2018·Journal of Oleo Science·Masaki Ujihara
Feb 12, 2021·ACS Nano·Chuan WangBin Hu
Oct 17, 2020·Nanotoxicology·Fatemeh Hataminia, Hossein Ghanbari
Dec 15, 2020·Scientific Reports·Sanae KannoYasuhiro Aoki
Aug 10, 2020·Chemico-biological Interactions·Yoke Ying TanDinesh Kumar Chellappan
May 3, 2019·Pharmacology & Therapeutics·Tanweer HaiderVandana Soni
Jun 11, 2020·Current Drug Metabolism·Shahad Saif KhandkerMd Sakib Hossen
Jul 22, 2021·Chemical Communications : Chem Comm·Eunbin Hwang, Hyo Sung Jung
Jan 12, 2022·ACS Applied Bio Materials·Ning GanTooru Ooya