Size-dependent effect of cystine/citric acid-capped confeito-like gold nanoparticles on cellular uptake and photothermal cancer therapy

Colloids and Surfaces. B, Biointerfaces
Wen Shang SawLip Yong Chung

Abstract

Physiochemical changes, including size, are known to affect gold nanoparticle cellular internalization and treatment efficacy. Here, we report the effect of four sizes of cystine/citric acid-coated confeito-like gold nanoparticles (confeito-AuNPs) (30, 60, 80 and 100nm) on cellular uptake, intracellular localization and photothermal anticancer treatment efficiency in MDA-MB231 breast cancer cells. Cellular uptake is size dependent with the smallest size of confeito-AuNPs (30nm) having the highest cellular internalization via clathrin- and caveolae-mediated endocytosis. However, the other three sizes (60, 80 and 100nm) utilize clathrin-mediated endocytosis for cellular uptake. The intracellular localization of confeito-AuNPs is related to their endocytosis mechanism, where all sizes of confeito-AuNPs were localized highly in the lysosome and mitochondria, while confeito-AuNPs (30nm) gave the highest localization in the endoplasmic reticulum. Similarly, a size-dependent trend was also observed in in vitro photothermal treatment experiments, with the smallest confeito-AuNPs (30nm) giving the highest cell killing rate, whereas the largest size of confeito-AuNPs (100nm) displayed the lowest photothermal efficacy. Its desirable physi...Continue Reading

Citations

Feb 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fengren WuBangshang Zhu
May 20, 2020·International Journal of Nanomedicine·Behzad NasseriThomas J Webster
Mar 27, 2020·International Journal of Nanomedicine·Somayeh KarimiReza Sheikhnejad
Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui Shan LiewMay Lee Low
Aug 10, 2020·Chemico-biological Interactions·Yoke Ying TanDinesh Kumar Chellappan
May 3, 2019·Pharmacology & Therapeutics·Tanweer HaiderVandana Soni
Jul 22, 2021·Chemical Communications : Chem Comm·Eunbin Hwang, Hyo Sung Jung

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