Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles

International Journal of Pharmaceutics
Hiroyuki KoideNaoto Oku

Abstract

An accelerated blood clearance (ABC) phenomenon is induced by repeated injections of poly(ethylene glycol)-modified (PEGylated) liposomes. We previously indicated that the phenomenon was induced by polymeric micelles possessing PEG chains like as liposomes, although, the induction mechanism of the ABC phenomenon is not fully elucidated. In the present study, we investigate whether repeat-injection of the polymeric micelles having PEG chains trigger the phenomenon or not. Two polymeric micelles, PM-30 (polymeric micelles with 33.6nm in diameter) and PM-75 (76.2nm), were prepared with PEG-poly[Asp(pentyl)] and PEG-poly[Asp(nonyl)], respectively. We firstly examined the ABC-triggering effect of these micelles, and observed that both polymeric micelles, especially PM-75, induced the production of anti-PEG IgM antibody in treated mice. Then, PM-30 or PM-75 was preadministered into mice as a preconditioning. Seven days later, AlexaFluor594-labeled PM-30 or PM-75 was administered to determine the susceptibility of the phenomenon. As a result, rapid clearance of AlexaFluor594-labeled PM-75 from the bloodstream and accumulation in the liver were observed in PM-75 pretreated mice. Although, the ABC phenomenon of AlexaFluor594-labeled PM-...Continue Reading

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Jul 1, 2008·International Journal of Pharmaceutics·Hiroyuki KoideNaoto Oku

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Citations

Apr 2, 2014·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Gianfranco Pasut
Jul 12, 2014·Journal of Drug Targeting·Masayuki Yokoyama
Apr 11, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Moritz Beck-BroichsitterPatrick Couvreur
Feb 25, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Qi Yang, Samuel K Lai
Dec 21, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kenji TsukigawaHiroshi Maeda
May 11, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kouichi ShiraishiMasayuki Yokoyama
Jun 15, 2016·Chemical Reviews·Jing M RenGreg G Qiao
Jan 25, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Fengling WangWeidong Chen
Jul 7, 2020·Journal of Microencapsulation·Naile OzturkImran Vural
Oct 25, 2020·Pharmaceutics·Nkiruka IbeanuSahar Awwad
Dec 19, 2013·Journal of the American Chemical Society·Antons SizovsJin Wang
Jun 30, 2018·Chemical Reviews·Horacio CabralKazunori Kataoka

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