Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems

ACS Applied Materials & Interfaces
Ting WangNan Chen

Abstract

Nanoparticles (NPs) have shown great promise as intracellular imaging probes or nanocarriers and are increasingly being used in biomedical applications. A detailed understanding of how NPs get "in and out" of cells is important for developing new nanomaterials with improved selectivity and less cytotoxicity. Both physical and chemical characteristics have been proven to regulate the cellular uptake of NPs. However, the exocytosis process and its regulation are less explored. Herein, we investigated the size-regulated endocytosis and exocytosis of carboxylated polystyrene (PS) NPs. PS NPs with a smaller size were endocytosed mainly through the clathrin-dependent pathway, whereas PS NPs with a larger size preferred caveolae-mediated endocytosis. Furthermore, our results revealed exocytosis of larger PS NPs and tracked the dynamic process at the single-particle level. These results indicate that particle size is a key factor for the regulation of intracellular trafficking of NPs and provide new insight into the development of more effective cellular nanocarriers.

References

Mar 7, 2003·Nature·Sean D Conner, Sandra L Schmid
Feb 4, 2010·Cell Research·Sudha KumariSatyajit Mayor
Aug 11, 2010·ACS Applied Materials & Interfaces·Xuli FengShu Wang
Mar 6, 2012·Chemical Society Reviews·Irene Canton, Giuseppe Battaglia
Jul 31, 2012·ACS Applied Materials & Interfaces·Yi ZhangBing Yan
Dec 6, 2012·Nature Nanotechnology·Marco P MonopoliKenneth A Dawson
Jan 11, 2013·Journal of the American Chemical Society·Anna LesniakChristoffer Åberg
Feb 14, 2013·ACS Applied Materials & Interfaces·Huan ZhangQing Huang
Feb 22, 2013·Journal of the Royal Society, Interface·Lennart TreuelGerd Ulrich Nienhaus
Apr 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Chung Hang J ChoiChad A Mirkin
May 29, 2013·Current Opinion in Chemical Biology·Wen-hong Li, Daliang Li
Sep 17, 2013·ACS Applied Materials & Interfaces·Weiqi ZhangHaiyan Xu
Sep 18, 2013·The Journal of Cell Biology·Hirohito NishimuraAkihiro Kusumi
Feb 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Julia VoigtV Prasad Shastri
Mar 5, 2014·Accounts of Chemical Research·Nan ChenChunhai Fan
Jan 1, 2013·Critical Reviews in Biomedical Engineering·James Chen Yong KahDawn Jing Hui Neo
Jul 1, 2014·ACS Applied Materials & Interfaces·Javier LinaresM Teresa Portolés
Feb 12, 2015·ACS Applied Materials & Interfaces·Han DingJiacong Shen
May 15, 2015·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Claudia StrobelIngrid Hilger
Oct 16, 2015·ACS Applied Materials & Interfaces·Thapakorn Tree-UdomSupason Wanichwecharungruang
Jan 19, 2016·Chemical Society Reviews·Mahdi KarimiMichael R Hamblin
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Edward A SykesWarren C W Chan
Mar 26, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Kristof ZarschlerKenneth A Dawson

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Citations

Nov 27, 2019·Nanotechnology·Francisca Villanueva-FloresLaura A Palomares
Apr 23, 2020·Pharmaceutics·Darío Manzanares, Valentín Ceña
Aug 9, 2018·International Journal of Molecular Sciences·Enrica ChiesaIda Genta
Jun 2, 2020·Biomedical Engineering Letters·Wan Su YunJaehong Key
May 13, 2018·Materials·Iwona Inkielewicz-StepniakMaria J Santos-Martinez
Aug 8, 2020·Biomaterials Science·Setayesh Yasami-KhiabaniMajid Golkar
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Bruna Gregatti de CarvalhoLucimara Gaziola de la Torre
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Na RenXin Yu
Sep 18, 2020·Advances in Colloid and Interface Science·Aoxue ZhangShuyu Xie
Dec 16, 2019·The Science of the Total Environment·Yuexiu QiuDayong Wang
Jun 9, 2021·Nature Communications·Chen ChenWei Min
Aug 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kathryn E HaleyAamir Hameed
Mar 4, 2020·ACS Central Science·Wenqi YuHuile Gao
Sep 3, 2021·Chemical Communications : Chem Comm·Yingcan ZhaoXingyu Jiang
Oct 9, 2021·Scientific Reports·Cassandra M StawickiParag Mallick

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