Size-dependent ROS production by palladium and nickel nanoparticles in cellular and acellular environments - An indication for the catalytic nature of their interactions

Nanotoxicology
Nicole NeubauerGerhard Kasper

Abstract

Palladium and nickel nanoparticles with variable but narrowly defined primary particle sizes in the range of 4-27 nm were investigated toward their catalytic activity and their ability to produce reactive oxygen species (ROS). The agglomerate size in the gas phase was between 50 and 150 nm, after transfer into solution probably larger. The catalytic activity was measured on the basis of CO oxidation to CO2. The formation of ROS was determined after transferring the particles into phosphate buffered saline (PBS), via the 2',7'-dichlorofluorescein method in a cell-free environment and with THP-1 cells. Activities were normalized with regard to catalyst surface area to enable a meaningful comparison of size effects. The solubility was measured for both materials and found to be 2 µg/ml for Ni and below the detection limit of 0.8 µg/ml for Pd. In the concentration range of about 4-250 µg/ml both materials induced a significant production of ROS in both acellular and cellular environments, with palladium being more active than nickel by several orders of magnitude. On an equal surface area concentration basis, both acellular and cellular ROS production showed a pronounced dependence on the primary particle size, with a maximum in th...Continue Reading

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Citations

Feb 2, 2016·Toxicology and Applied Pharmacology·Christian RiebelingAndrea Haase
Dec 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sangiliyandi GurunathanJin-Hoi Kim
Mar 25, 2016·Journal of Molecular Histology·Ruth MagayeJinshun Zhao
Feb 8, 2018·International Journal of Molecular Sciences·Veruscka Leso, Ivo Iavicoli
Oct 5, 2019·Nanoscale·Marta QuintanillaLuis M Liz-Marzán
Jan 18, 2020·Nanomaterials·Mauro MoglianettiPier Paolo Pompa
Sep 12, 2019·Chemico-biological Interactions·Keywan MortezaeeAmirhossein Ahmadi
Jan 25, 2021·The Science of the Total Environment·Mateusz OlejnikMatthias Epple

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