Size dependent skin penetration of nanoparticles in murine and porcine dermatitis models

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Celine TryAlf Lamprecht

Abstract

A major limitation in the current topical treatment of inflammatory skin diseases is the inability to selectively deliver the drug to the inflammation site. Recently, smart drug delivery systems such as nanocarriers are being investigated to enhance the selective deposition of anti-inflammatory drugs in inflamed areas of the skin to achieve higher therapeutic efficacy with minimal side effects. Of such systems, polymeric nanoparticles are considered very efficient carriers for the topical drug delivery. In the current work, poly(l-lactide-co-glycolide) nanoparticles of nominal sizes of 70nm (NP70) and 300nm (NP300) were studied for their intra-epidermal distribution in murine and pig atopic dermatitis models over time against the respective healthy controls. Confocal laser scanning microscopical examination of skin biopsies was utilized for the qualitative and semi-quantitative analyses of nanoparticles skin deposition and penetration depth. While no skin penetration was found for any of the particles in healthy skin, the accumulation of NP70 was significantly higher than NP300 in inflamed skin (15-fold in mice, 5-fold in pigs). Penetration depth of NP70 decreased over time in mice from 55±3μm to 20±2μm and similar tendencies w...Continue Reading

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Citations

Nov 5, 2016·International Journal of Pharmaceutics·Mona M A Abdel-Mottaleb, Alf Lamprecht
Aug 19, 2020·Drug Development and Industrial Pharmacy·Diana G SamiHassan M E Azzazy
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Mar 10, 2019·Nature Communications·Christian WirajaChenjie Xu
Jan 25, 2021·AAPS PharmSciTech·Khushali ParekhAmirali Popat
Feb 8, 2021·International Journal of Pharmaceutics·Eleonora MarettiValentina Iannuccelli
Jun 21, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·John YoushiaAlf Lamprecht
Jul 3, 2021·International Journal of Molecular Sciences·Jiun-Wen Guo, Shiou-Hwa Jee

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