Size-dependent superparamagnetic iron oxide nanoparticles dictate interleukin-1β release from mouse bone marrow-derived macrophages

Journal of Applied Toxicology : JAT
Shuzhen ChenGang Liu

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely investigated for their biomedical applications in magnetic resonance imaging, targeting therapy, cell labeling, etc. It has been well documented that macrophages produce interleukin (IL)-1β via several signaling pathways, such as inflammasome activation in response to particles including silica, asbestos and urea crystals with lipopolysaccharide priming. However, the size and dose effects of SPIONs on macrophages and the mechanisms remain unclear. In this study, we explored the cytotoxicity and mechanisms of the synthesized SPIONs with different size distributions of 30, 80 and 120 nm, and compared their potential capability in inducing IL-1β release in mouse bone marrow-derived macrophages (BMMs). We found that SPIONs induced IL-1β release in a size- and dose-dependent manner, in which the smallest SPIONs triggered the highest IL-1β in BMMs. When cellular uptake of SPIONs was inhibited by the actin polymerization inhibitor, cytochalasin D, SPION-induced IL-1β release was suppressed in BMMs. Preventing lysosome damage with bafilomycin A1 or CA-074-Me also counteracted SPION-induced IL-1β release. Moreover, SPION-activated IL-1β release was also attenuated by r...Continue Reading

References

Oct 14, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·D M BrownV Stone
Feb 4, 2006·Science·Andre NelNing Li
Aug 20, 2008·Chemical Research in Toxicology·Hanna L KarlssonLennart Möller
Oct 4, 2008·The Journal of Physical Chemistry. B·C CarlsonJ J Schlager
Mar 3, 2009·Immunobiology·Claudia Eder
Sep 22, 2010·International Journal of Nanomedicine·Bao-An ChenXuemei Wang
Apr 29, 2011·The Journal of Biological Chemistry·Anna C ReisetterMartha M Monick
Feb 22, 2012·Nanoscale Research Letters·Abolfazl AkbarzadehSoodabeh Davaran
Aug 14, 2012·Particle and Fibre Toxicology·Wiggo J SandbergMagne Refsnes
Mar 23, 2013·Protein & Cell·Shuzhen Chen, Bing Sun
Sep 7, 2013·Biochimica Et Biophysica Acta·Rafael Gregorio MendesMark Hermann Rümmeli
May 27, 2014·Cell·Mohamed Lamkanfi, Vishva M Dixit
Nov 11, 2014·Beilstein Journal of Nanotechnology·Dagmar A KuhnBarbara Rothen-Rutishauser
Jan 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kairui MaoBing Sun
Apr 17, 2015·Immunological Reviews·Eric I Elliott, Fayyaz S Sutterwala
Sep 22, 2015·Chemical Society Reviews·Hamed AramiKannan M Krishnan
Oct 13, 2015·BioImpacts : BI·Jaleh Barar
Dec 24, 2015·Nanoscale·Zhaohui WuWei Wu
Jan 14, 2016·Journal of Occupational Medicine and Toxicology·Takamitsu Miyayama, Masato Matsuoka
Jan 24, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anurag MishraPeter L Goering
May 25, 2016·Nanoscale Research Letters·Shuzhen ChenZhongning Lin
Jun 18, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kana NakanishiShuji Kojima
Jul 19, 2016·Journal of Nanoscience and Nanotechnology·Zhongyan ZhangHua Zhang
Sep 28, 2016·Trends in Biochemical Sciences·Yuan HeGabriel Núñez
Oct 4, 2016·International Journal of Nanomedicine·Susann GrosseAsbjørn M Nilsen
Feb 1, 2017·Nature Reviews. Immunology·Ine JorgensenEdward A Miao
Apr 13, 2017·Particle and Fibre Toxicology·Misato TsugitaMasafumi Nakayama
Jun 6, 2017·International Journal of Nanomedicine·Susann Wolf-GrosseJørgen Stenvik

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Citations

May 10, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Zeng HeLibo Du
Apr 25, 2020·Bulletin of Experimental Biology and Medicine·I V MiltoI V Sukhodolo
May 21, 2020·Royal Society Open Science·Shan ZhangShourong Shi
Aug 30, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Janin ReifenrathNina Angrisani
Jul 3, 2021·Frontiers in Immunology·Mark Geppert, Martin Himly
Jul 22, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Seokhwan ChungMiqin Zhang
Jul 27, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lihua HeKai Hua
Nov 7, 2018·ACS Applied Materials & Interfaces·Liu LiuLong-Ping Wen
Oct 28, 2021·Bulletin of Experimental Biology and Medicine·I V Mil'toI V Sukhodolo

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