Size-fractionated particulate air pollution and circulating biomarkers of inflammation, coagulation, and vasoconstriction in a panel of young adults
Abstract
Short-term associations between size-fractionated particulate air pollution and circulating biomarkers are not well established, especially in developing countries with high levels of particulate matter (PM). We designed a panel study involving 34 healthy young adults to evaluate acute effects of size-fractionated PM on 13 circulating biomarkers of inflammation, coagulation, and vasoconstriction. We measured real-time, size-fractionated number concentrations of PM (aerodynamic diameters from 0.25 to 10 μm, mass concentrations of PM < 10 μm) over four follow-up measurements. The short-term associations between size-fractionated PM and biomarkers were assessed using linear mixed effect models. We found positive associations between short-term exposure to PM and 10 biomarkers. PM with smaller size had stronger associations. The size fractions with the strongest associations were 0.25-0.40 μm for number concentrations and <1 μm for mass concentrations. For example, an interquartile range increase in 24-hour-average number concentrations of PM0.25-0.40 was associated with a 7%-32% increase in biomarkers of inflammation, 34%-68% of blood coagulation, and 45% of vasoconstriction. Similar estimates were found for mass concentrations of...Continue Reading
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Fine Particulate Matter Constituents, Nitric Oxide Synthase DNA Methylation and Exhaled Nitric Oxide
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