Size-fractionated particulate air pollution and circulating biomarkers of inflammation, coagulation, and vasoconstriction in a panel of young adults

Epidemiology
Renjie ChenHaidong Kan

Abstract

Short-term associations between size-fractionated particulate air pollution and circulating biomarkers are not well established, especially in developing countries with high levels of particulate matter (PM). We designed a panel study involving 34 healthy young adults to evaluate acute effects of size-fractionated PM on 13 circulating biomarkers of inflammation, coagulation, and vasoconstriction. We measured real-time, size-fractionated number concentrations of PM (aerodynamic diameters from 0.25 to 10 μm, mass concentrations of PM < 10 μm) over four follow-up measurements. The short-term associations between size-fractionated PM and biomarkers were assessed using linear mixed effect models. We found positive associations between short-term exposure to PM and 10 biomarkers. PM with smaller size had stronger associations. The size fractions with the strongest associations were 0.25-0.40 μm for number concentrations and <1 μm for mass concentrations. For example, an interquartile range increase in 24-hour-average number concentrations of PM0.25-0.40 was associated with a 7%-32% increase in biomarkers of inflammation, 34%-68% of blood coagulation, and 45% of vasoconstriction. Similar estimates were found for mass concentrations of...Continue Reading

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Citations

Sep 16, 2015·Environmental Science & Technology·Renjie ChenHaidong Kan
Apr 23, 2016·Environmental Research·Yueh-Hsiu Mathilda ChiuFrancine Laden
Jun 5, 2016·Environmental Pollution·Hualiang LinLinwei Tian
Jun 14, 2016·The Science of the Total Environment·Jing CaiHaidong Kan
Jan 6, 2017·Environmental Science & Technology·Shujing ChenHaidong Kan
Jun 18, 2017·Environmental Science & Technology·Cong LiuHaidong Kan
Aug 11, 2015·International Journal of Environmental Research and Public Health·Julia WaselAlexander Gerber
Feb 16, 2018·Environmental Science and Pollution Research International·Haiyan ChuMeilin Wang
Aug 27, 2016·Environmental Health Perspectives·Jingjin ShiHaidong Kan
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Jan 27, 2021·International Journal of Environmental Research and Public Health·Jongmin OhEunhee Ha
Oct 4, 2020·Ecotoxicology and Environmental Safety·Mengqi SunJunchao Duan
Mar 28, 2021·Environmental Science and Pollution Research International·Sha LiJiahu Hao

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