Size of Extranodal Extension on Sentinel Lymph Node Dissection in the American College of Surgeons Oncology Group Z0011 Trial Era

JAMA Surgery
Audrey H ChoiMaheswari Senthil

Abstract

Based on the American College of Surgeons Oncology Group Z0011 trial exclusion criteria, patients with T1N0 or T2N0 breast cancer with 1 or 2 positive sentinel lymph nodes (SLNs) are recommended to undergo axillary lymph node dissection if extranodal extension (ENE) is present. To determine the effect of ENE size on residual axillary nodal burden, disease recurrence, and survival in patients meeting Z0011 criteria. Retrospective cohort study between January 1, 2000, and December 31, 2012, at a single tertiary cancer center. Patients had T1 or T2 breast cancer with 1 or 2 positive SLNs. The ENE was classified as 2 mm or smaller or as larger than 2 mm. Nodal burden, disease recurrence, and overall survival. Of 208 patients, 149 (71.6%) had no ENE, 21 (10.1%) had ENE 2 mm or smaller, and 38 (18.3%) had ENE larger than 2 mm on SLN dissection. The median follow-up time was 60 months (range, 1-158 months). The mean (SD) total number of positive lymph nodes differed significantly for the group with no ENE (1.72 [1.39]) vs the group with ENE 2 mm or smaller (3.22 [2.09]; P < .001) and vs the group with ENE larger than 2 mm (4.26 [5.01]; P < .001). Similar patterns were observed for mean (SD) nonsentinel lymph node metastases: 0.48 (1.3...Continue Reading

Citations

Mar 24, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A NottegarC Luchini
Jul 30, 2016·Archives of Pathology & Laboratory Medicine·Aoife Maguire, Edi Brogi
Jan 6, 2019·Breast Cancer Research and Treatment·Marissa L G VaneMarjolein L Smidt
Jul 7, 2019·International Journal of Molecular Sciences·Isao Otsuka
May 11, 2018·American Journal of Clinical Pathology·Beth T Harrison, Jane E Brock
Jan 20, 2021·Journal of Pathology and Translational Medicine·Soo Youn ChoHye Kyoung Yoon
Feb 27, 2021·Journal of breast cancer·Soo Youn ChoHye Kyoung Yoon
May 1, 2021·Surgical Oncology·Macerly Layse de Menezes DantasDiana Taissa Sampaio Marinho Navarro

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