Size reduction of macroprolactinomas by bromocriptine or lisuride treatment

The Journal of Clinical Endocrinology and Metabolism
P G ChiodiniR Horowski

Abstract

We have administered to 29 patients with macroprolactinoma the dopamine agonists bromocriptine and lisuride for 1-50 months (mean +/- SE, 12.7 +/- 1.8) in order to assess the effects of these drugs on tumor size. Fourteen patients were treated with bromocriptine (dose range, 7.5-20 mg/day), 12 patients were treated with lisuride (0.6-2 mg/day), and 3 patients were given both drugs. Computed tomography performed before and during treatment showed the occurrence of tumor shrinkage in 18 patients (62%), but in no case was a complete disappearance of the tumor observed. In 5 of these patients, it was even possible to document tumor shrinkage within the first month of treatment with low doses of the dopamine agonists, whereas in other patients, tumors shrank only after prolonged treatment with higher doses. Visual field and acuity improved or normalized in 8 of the 13 patients with visual defects; in some cases, the improvement was reported as early as 2 days after the treatment was started. Plasma PRL levels fell in all patients who showed a reduction in tumor size; in 2 other patients, PRL levels were only poorly suppressed, and tumor size remained unchanged. In the remaining patients, PRL levels were lowered without convincing ev...Continue Reading

Citations

Jan 15, 1992·Microscopy Research and Technique·W Saeger
Jan 1, 1985·The American Journal of Medicine·F Wollesen, B B Bendsen
Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·D ZierhutM Wannenmacher
Sep 22, 1983·The New England Journal of Medicine·D L KleinbergC J Sommers
Sep 12, 1985·The New England Journal of Medicine·A LiuzziG Luccarelli
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C MissaleP Spano
Jun 26, 1982·British Medical Journal·J A WassG M Besser
Aug 13, 1983·British Medical Journal·H D BreidahlJ W Pike
May 23, 1987·British Medical Journal·P M BoulouxP J Moult
Jun 7, 2000·Drugs·B Fautrel, P Bourgeois
Jul 1, 1985·Journal of Neurosurgery·A A KemenyR Wojcikiewicz
Dec 1, 1987·Journal of Neurosurgery·R FahlbuschU Schrell
Apr 1, 1988·Journal of Neurosurgery·D L BarrowG T Tindall
Jul 1, 1993·Journal of Neurosurgery·M H BrismanKalmon D Post
Dec 1, 1996·Journal of Neurosurgery·M H BrismanKalmon D Post
Aug 21, 2002·Journal of Neurosurgery·Raj K ShrivastavaKalmon D Post
Jul 13, 1999·Journal of Endocrinological Investigation·S CannavòF Trimarchi
Jun 1, 1993·Journal of Endocrinological Investigation·D SchwarzsteinS M Webb
Oct 1, 1985·Ophthalmology·M L MosterT M Bosley
Jun 1, 1986·Pathology, Research and Practice·H SchottkeJ Caselitz
May 16, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Chirag G PatilSteven D Chang
Jan 1, 1994·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B MerolaG Lombardi
Oct 1, 1989·Clinical Endocrinology·C B NewmanD L Kleinberg
May 1, 1985·Clinical Endocrinology·A GrossmanG M Besser
Dec 1, 1982·Clinical Endocrinology·T BerghL Wide
May 1, 1986·Clinical Endocrinology·G BenkerD Reinwein
Mar 1, 1983·Clinics in Endocrinology and Metabolism·M J Cronin, W S Evans
Jan 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M F RibeiroF M Reis
May 23, 1987·British Medical Journal·C J Bushe
Jan 1, 1987·Acta neurochirurgica·B GuidettiG P Cantore
Jan 1, 1985·Neurosurgical Review·R Fahlbusch, M Buchfelder
Aug 1, 1990·Postgraduate Medicine·E D WhiteheadP Salkin
Apr 15, 1985·Klinische Wochenschrift·R LandgrafK von Werder
Sep 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·B MerolaC Nappi
Nov 1, 1982·Journal of Endocrinological Investigation·M NissimG Faglia
Jul 2, 1987·The New England Journal of Medicine·P J GuillausseauJ Lubetski
Jan 19, 1985·British Medical Journal·A Grossman, G M Besser
Feb 1, 1983·Journal of Endocrinological Investigation·D DallabonzanaA Liuzzi
Jun 1, 1984·Asia-Oceania Journal of Obstetrics and Gynaecology·R J Pepperell
Jun 1, 1985·Journal of Endocrinological Investigation·A LiuzziG Verde
Mar 16, 2000·Drugs·J J Orrego, A L Barkan

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Parlodel
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