PMID: 9167509Jun 1, 1997Paper

Size, shape, and orientation of neurons in the left and right hippocampus: investigation of normal asymmetries and alterations in schizophrenia

The American Journal of Psychiatry
D W ZaidelP J Harrison

Abstract

Schizophrenia may involve the two cerebral hemispheres differentially. This study was conducted to determine whether left and right hippocampal neuronal size, shape, and orientation are normally asymmetrical or asymmetrically affected in schizophrenia. The authors examined postmortem tissue from the left and right hippocampus of 17 normal individuals and 14 individuals with schizophrenia. They measured the size, shape, and variability in orientation of pyramidal neurons in hippocampal subfields CA1-CA4 and the subiculum in computer images of 10-micron coronal sections stained with cresyl violet. Both neuronal size and shape showed significant effects of diagnosis and a three-way interaction between diagnosis, hemisphere, and subfield. Neurons of the schizophrenic subjects were smaller than those of the normal subjects in the left CA1, left CA2, and right CA3 subfields; their shape differed from that of the normal subjects in the left CA1, left subiculum, and right CA3 subfields. There were no group differences in variability of neuronal orientation, but neurons in the CA3 genu in the schizophrenic subjects were less variable on the right than on the left. In the normal subjects, except for larger neurons in the left than in the...Continue Reading

Citations

Jan 1, 2014·European Archives of Psychiatry and Clinical Neuroscience·M R WilliamsM Maier
Sep 9, 2008·Acta Neuropathologica·Andrea SchmittPeter Falkai
Jul 20, 2002·Brain Research. Developmental Brain Research·William M HumphreyJohn G Csernansky
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