Size, Shape, and Protein Corona Determine Cellular Uptake and Removal Mechanisms of Gold Nanoparticles

Small
Lin DingMinghong Wu

Abstract

Size, shape, and protein corona play a key role in cellular uptake and removal mechanisms of gold nanoparticles (Au NPs). The 15 nm nanoparticles (NP1), the 45 nm nanoparticles (NP2), and the rod-shaped nanoparticles (NR) enter into cells via a receptor-mediated endocytosis (RME) pathway. The star-shaped nanoparticles (NS) adopt not only clathrin-mediated, but also caveolin-mediated endocytosis pathways. However, the 80 nm nanoparitcles (NP3) mainly enter into the cells by macropinocytosis pathway due to the big size. Furthermore, the results indicate that the presence of protein corona can change the uptake mechanisms of Au NPs. The endocytosis pathway of NP1, NP2, and NS changes from RME to macropinocytosis pathway and NR changes from RME to clathrin and caveolin-independent pathway under the non-fetal bovine serun (FBS)-coated condition. Both FBS-coated and non-FBS-coated of five types of Au NPs are released out through the lysosomal exocytosis pathway. The size, shape, and protein corona have an effect on the exocytosis ratio and amount, but do not change the exocytosis mechanism. The systematic study of the endocytosis and exocytosis mechanism of Au NPs with different sizes and shapes will benefit the toxicology evaluation...Continue Reading

References

Jul 25, 1996·Biochimica Et Biophysica Acta·Z MamdouhC Le Grimellec
Apr 28, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T BabaS Ohno
Mar 7, 2003·Nature·Sean D Conner, Sandra L Schmid
Jul 22, 2004·Bioconjugate Chemistry·Catherine M GoodmanVincent M Rotello
Jun 21, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Joanna RejmanMassimo Conese
Jun 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Huajian GaoLambert B Freund
Apr 13, 2006·Nano Letters·B Devika ChithraniWarren C W Chan
Jun 3, 2006·Developmental Cell·Eric MaciaTomas Kirchhausen
Jul 5, 2007·Nature Reviews. Molecular Cell Biology·Satyajit Mayor, Richard E Pagano
Oct 24, 2007·Journal of the American Chemical Society·Xiaohui JiXiaogang Peng
Jul 23, 2008·Journal of the American Chemical Society·Yu ChengClemens Burda
Feb 12, 2009·ACS Nano·Paola NativoMathias Brust
Mar 11, 2010·Methods in Molecular Biology·Leslie AuYounan Xia
Apr 26, 2011·Nature Nanotechnology·Eun Chul ChoYounan Xia
Jul 23, 2011·Nature Reviews. Molecular Cell Biology·Harvey T McMahon, Emmanuel Boucrot
Sep 1, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Tingting WangXiaomeng Li
Oct 26, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·I-Chun LinIstvan Toth
Mar 6, 2012·Chemical Society Reviews·Irene Canton, Giuseppe Battaglia
Jul 24, 2012·Nano Letters·Marisa Maltez-da CostaArben Merkoçi
Nov 28, 2012·Advanced Healthcare Materials·Tao ChenShaobing Zhou
Aug 21, 2013·ACS Applied Materials & Interfaces·Emily A UntenerSaber M Hussain
Jan 1, 2008·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Christopher G Khoury, Tuan Vo-Dinh
Apr 30, 2014·Journal of the American Chemical Society·Zhenjiang ZhangChunying Chen
Sep 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Joel P BaumgartHugh C Hemmings

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Citations

Nov 13, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Wen LiYuanyan Liu
Sep 27, 2019·Journal of Tissue Engineering·Rajendra K SinghHae-Won Kim
Apr 23, 2020·Pharmaceutics·Darío Manzanares, Valentín Ceña
Apr 7, 2020·Nanomedicine·Muhammad OvaisChunying Chen
Nov 27, 2019·Cancers·Lucia SalvioniDavide Prosperi
Dec 14, 2018·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Cecilia Fernández-PonceRocío Litrán
Oct 19, 2019·Journal of Nanobiotechnology·Ismael Plaza-GaIván López Montero
Jul 21, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ivan Kempson
Oct 7, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Sandra Estalayo-AdriánThorfinnur Gunnlaugsson
Feb 16, 2021·ACS Applied Materials & Interfaces·Yadileiny PortillaDomingo F Barber
Apr 12, 2021·Journal of Colloid and Interface Science·Vincenzo AmendolaPasquina Marzola
May 11, 2021·Frontiers in Pharmacology·Shengnan LiaoJinfeng Liao
May 26, 2021·The Science of the Total Environment·Ling LiuWei Jiang
Jun 5, 2021·Advanced Drug Delivery Reviews·Yiyuan KangLongquan Shao
Aug 21, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Junchao LuoQing Bi
Sep 16, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Mehavesh HameedAhmed A Mohamed
Aug 30, 2021·Advances in Colloid and Interface Science·Bijaideep DuttaP A Hassan
Dec 9, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zahid Ullah KhanMagnus Gidlund

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