PMID: 8987261Jun 1, 1996Paper

Sizing emboli in blood using pulse Doppler ultrasound--I: Verification of the EBR model

IEEE Transactions on Bio-medical Engineering
M A Moehring, J A Ritcey

Abstract

An experiment to verify a theory describing ultrasound backscattering from emboli in flowing blood is presented. The theoretical predictions for the backscattered power versus embolus size are based on the measurement of the embolus to blood ratio (EBR) of backscattered acoustic power. This tool is necessary for in vivo clinical application because it removes the need to characterize attenuation and reflection loss in heterogeneous tissue. The experiment presented utilizes a customized ultrasound pulse Doppler that is capable of interrogating a sample volume with two different frequencies concurrently. A flow circuit including a 3.6-mm-diameter conduit in polyacrylamide gel in which emboli are observed with the dual frequency Doppler is described. The flow within the circuit has acoustic backscatter coefficient similar to blood due to a calibrated concentration of 31.1-mu diameter polystyrene microspheres. Polystyrene microsphere "emboli" having nominal diameters of 161 and 239 mu are placed in this flow loop and time series Doppler shift signatures are recorded. These signatures are investigated and a refraction artifact hypothesis is proposed to explain systematic deviation of the signatures away from theoretically expected r...Continue Reading

References

Mar 1, 1990·Stroke; a Journal of Cerebral Circulation·M P SpencerL R Sauvage
Mar 1, 1988·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·E J Boote, J A Zagzebski
Jan 1, 1986·IEEE Transactions on Bio-medical Engineering·L Y Mo, R S Cobbold
Jan 1, 1994·IEEE Transactions on Bio-medical Engineering·M A Moehring, J R Klepper
Jun 1, 1996·IEEE Transactions on Bio-medical Engineering·M A MoehringA Ishimaru

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Citations

Jun 22, 1999·Ultrasound in Medicine & Biology·E RoyJ L Saumet
Sep 1, 1996·Echocardiography·Mark A. Moehring, James A. Ritcey
Aug 29, 2009·Cerebrovascular Diseases·Matthew J MartinDavid H Evans
Feb 7, 2012·Ultrasound in Medicine & Biology·Jakub Zmigrodzki, Krzysztof Kaluzynski
Jun 1, 2010·Ultrasound in Medicine & Biology·Martin O CuljatRahul S Singh
Sep 15, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Georges A DarbellayGérald Devuyst
Jul 5, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Rosendo A RodriguezHoward J Nathan
Nov 28, 2009·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Sung-Liang ChenL Jay Guo
Jul 29, 2006·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Denis KouaméAurore Bleuzen
Jun 1, 1996·IEEE Transactions on Bio-medical Engineering·M A MoehringA Ishimaru
Sep 24, 1999·IEEE Transactions on Bio-medical Engineering·B S KrongoldD L Jones
Jan 25, 2003·Journal of Biomedical Optics·Kenneth SolenFazal Mohammad
May 27, 2003·The Journal of the Acoustical Society of America·Isabelle Fontaine, Guy Cloutier
May 9, 2000·Ultrasonic Imaging·L SandrinM Fink

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