SK channels and ventricular arrhythmias in heart failure

Trends in Cardiovascular Medicine
Po-Cheng Chang, Peng-Sheng Chen

Abstract

Small-conductance Ca(2+)-activated K(+) (SK) currents are important in the repolarization of normal atrial (but not ventricular) cardiomyocytes. However, recent studies showed that the SK currents are upregulated in failing ventricular cardiomyocytes, along with increased SK channel protein expression and enhanced sensitivity to intracellular Ca(2+). The SK channel activation may be either anti-arrhythmic or pro-arrhythmic, depending on the underlying clinical situations. While the SK channel is a new target of anti-arrhythmic therapy, drug safety is still one of the major concerns.

References

Nov 1, 1988·The Journal of Physiology·W R Giles, Y Imaizumi
Jan 1, 1984·Pharmacology & Therapeutics·E Habermann
Oct 16, 2004·Circulation Research·Gordon F Tomaselli, Douglas P Zipes
Aug 2, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dipika TutejaNipavan Chiamvimonvat
Dec 22, 2007·Circulation Research·Qian ZhangNipavan Chiamvimonvat
May 27, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masahiro OgawaPeng-Sheng Chen
Jul 28, 2009·Journal of Molecular and Cellular Cardiology·Norbert NagyAndrás Tóth
Nov 13, 2009·Current Opinion in Cardiology·Takeshi Aiba, Gordon F Tomaselli
Feb 10, 2010·British Journal of Pharmacology·Chris E PollardJ-P Valentin
Feb 23, 2010·Nature Genetics·Patrick T EllinorStefan Kääb
Apr 3, 2010·Progress in Neurobiology·Kate L WeatherallNeil V Marrion
Jun 22, 2010·Circulation. Arrhythmia and Electrophysiology·Jonas Goldin DinessRie Schultz Hansen
Sep 29, 2011·Annual Review of Physiology·John P AdelmanPankaj Sah
Dec 14, 2011·Pflügers Archiv : European journal of physiology·Gillian E MarshallAntony J Workman
May 1, 2012·Nature Genetics·Patrick T EllinorStefan Kääb
Oct 23, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Le GuiQing-Hui Chen
Jan 30, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mark J ShenPeng-Sheng Chen
Feb 5, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Chia-Hsiang HsuehShien-Fong Lin
Feb 20, 2013·Circulation. Arrhythmia and Electrophysiology·Yu-Cheng HsiehPeng-Sheng Chen
May 31, 2013·Journal of Cardiovascular Electrophysiology·Young Soo LeePeng-Sheng Chen
Aug 8, 2013·PloS One·Isik TurkerTomohiko Ai
Dec 4, 2013·Cardiovascular Research·Saagar MahidaPatrick T Ellinor
Jan 2, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Dmitry TerentyevWeiyan Li
Apr 30, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Attila FeherZsolt Bagi

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Citations

Jun 5, 2016·Cardiac Electrophysiology Clinics·Jeanne M Nerbonne
Mar 11, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Wei-Chung TsaiPeng-Sheng Chen
Apr 7, 2015·Trends in Cardiovascular Medicine·David R Van Wagoner
May 12, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Chih-Chieh YuPeng-Sheng Chen
Feb 27, 2016·Expert Opinion on Therapeutic Targets·Jules C HancoxDierk Thomas
Jul 22, 2016·Medicine·Chih-Chieh YuJiunn-Lee Lin
Dec 3, 2016·The Journal of Physiology·Matthew KennedyDaisuke Sato
Jul 12, 2017·Expert Opinion on Investigational Drugs·Jordi HeijmanDobromir Dobrev
May 28, 2017·Journal of the American Heart Association·Thomas A ReherPeng-Sheng Chen
Jan 13, 2019·The Journal of Biological Chemistry·Tian-You LingHon-Chi Lee
May 30, 2020·Journal of the American Heart Association·Mark A MungerPrzemysław B Radwański
Jun 11, 2017·The Biochemical Journal·Charles Owen SmithPaul S Brookes
Apr 14, 2018·Experimental & Molecular Medicine·Mingxia GuDai-Min Zhang
Mar 20, 2018·Scientific Reports·Xiao-Dong ZhangNipavan Chiamvimonvat
Feb 25, 2021·Pflügers Archiv : European journal of physiology·Xiao-Dong ZhangNipavan Chiamvimonvat
Mar 2, 2021·Heart, Lung & Circulation·Miao-Miao QiRu-Xing Wang
Jul 16, 2020·Biophysical Journal·Peter BronkBum-Rak Choi

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