SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons.

Neuroscience
J DeignanJohn P Adelman

Abstract

The firing properties of dopamine (DA) neurons in the substantia nigra (SN) pars compacta are strongly influenced by the activity of apamin-sensitive small conductance Ca(2+)-activated K(+) (SK) channels. Of the three SK channel genes expressed in central neurons, only SK3 expression has been identified in DA neurons. The present findings show that SK2 was also expressed in DA neurons. Immuno-electron microscopy (iEM) showed that SK2 was primarily expressed in the distal dendrites, while SK3 was heavily expressed in the soma and, to a lesser extent, throughout the dendritic arbor. Electrophysiological recordings of the effects of the SK channel blocker apamin on DA neurons from wild type and SK(-/-) mice show that SK2-containing channels contributed to the precision of action potential (AP) timing, while SK3-containing channels influenced AP frequency. The expression of SK2 in DA neurons may endow distinct signaling and subcellular localization to SK2-containing channels.

References

Oct 18, 2002·Neuron·Wolfram Schultz
Jun 11, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chris T BondJohn P Adelman
Mar 31, 2005·The Journal of Biological Chemistry·Timothy StrassmaierJohn P Adelman
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lev KoyrakhKevin Wickman
Dec 18, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Gail Tripp, Jeff R Wickens
Jan 22, 2008·Nature Neuroscience·Mike T LinJames Maylie
Jul 29, 2008·Nature Neuroscience·Christopher D FiorilloWolfram Schultz
Dec 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ilva PutzierEdwin S Levitan
Mar 11, 2010·Journal of Computational Neuroscience·Anna Y KuznetsovaCarmen C Canavier
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kate L WeatherallNeil V Marrion

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Citations

Nov 6, 2013·The European Journal of Neuroscience·Philippe AlixVincent Seutin
Apr 12, 2014·Journal of Neuroscience Research·Martial A DufourJean-Marc Goaillard
Jan 11, 2014·The European Journal of Neuroscience·Carmen Ballesteros-MerinoRafael Luján
Apr 2, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul F Kramer, John T Williams
Feb 11, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Audrey E PadulaPatrick J Mulholland
Jan 8, 2015·Frontiers in Neuroanatomy·Carmen Ballesteros-MerinoRafael Luján
Sep 9, 2017·Neuroscience Bulletin·Xiaoyan ChenJunxia Xie
Mar 27, 2018·Bioinformatics·Claudia GiambartolomeiPanos Roussos
Mar 6, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Fui C YapMike T Lin
Mar 25, 2017·Neuroscience Bulletin·Xiaodan HuangChangzheng Zhang
Mar 3, 2021·The Journal of Physiology·Laetitia EtchepareLaurent Groc
Mar 27, 2021·Annual Review of Neuroscience·Jean-Marc Goaillard, Eve Marder

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