Skate cartilage extracts containing chondroitin sulfate ameliorates hyperlipidemia-induced inflammation and oxidative stress in high cholesterol diet-fed LDL receptor knockout mice in comparison with shark chondroitin sulfate

Nutrition Research and Practice
Bo Gyeong SeolEun Ju Cho

Abstract

In this study, we investigated the beneficial effects of skate cartilage extracts containing chondroitin sulfate (SCS) on hyperlipidemia-induced inflammation and oxidative stress in high cholesterol diet (HCD)-fed mice in comparison with the effects of shark cartilage-derived chondroitin sulfate (CS). Low-density lipoprotein receptor knockout (LDLR-KO) mice were fed HCD with an oral administration of CS (50 and 100 mg/kg BW/day), SCS (100 and 200 mg/kg BW/day), or water, respectively, for ten weeks. The administration of CS or SCS reduced the levels of serum triglyceride (TG), total cholesterol (TC), and LDL cholesterol and elevated the levels of high-density lipoprotein cholesterol, compared with those of the control group (P < 0.05). Furthermore, CS or SCS significantly attenuated inflammation by reducing the serum levels of interleukin (IL)-1β and hepatic protein expression levels of nuclear factor kappa B, inducible nitric oxide synthase, cyclooxygenase-2, and IL-1beta (P < 0.05). In particular, the serum level of tumor necrosis factor-alpha was reduced only in the 100 mg/kg BW/day of SCS-fed group, whereas the IL-6 level was reduced in the 100 and 200 mg/kg BW/day of SCS-fed groups (P < 0.05). In addition, lipid peroxidati...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1987·European Journal of Applied Physiology and Occupational Physiology·R LovlinA N Belcastro
Jul 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·A C CarrB Frei
Oct 18, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L K HanH Okuda
Jun 12, 2003·Cardiovascular Research·Annamária OnodyPéter Ferdinandy
Nov 13, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nageswara R MadamanchiMarschall S Runge
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Jul 14, 2007·European Journal of Pharmacology·László CzakóJános Lonovics
Sep 22, 2007·The Journal of Pharmacology and Experimental Therapeutics·Noelia CañasManuela G López
Mar 11, 2008·Expert Review of Cardiovascular Therapy·Lisa R Tannock
May 20, 2008·Cardiovascular Research·Robert KleemannTeake Kooistra
Jul 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kristiaan WoutersMarten H Hofker
Apr 12, 2011·Expert Review of Gastroenterology & Hepatology·R Christopher HarmonCurtis K Argo
Jun 22, 2011·Journal of Lipid Research·Savitha SubramanianAlan Chait
Sep 3, 2011·Osteoarthritis and Cartilage·K BauerovaN Volpi
Feb 22, 2012·Journal of Physiology and Biochemistry·Isabel Bondia-PonsJ Alfredo Martinez
Feb 14, 2013·Primary Care·Robert H Nelson
Apr 30, 2013·International Journal of Biological Macromolecules·Imen DahechKarima Srih Belghith
Aug 27, 2013·Free Radical Biology & Medicine·Jhuli Keli AngeliDalton Valentim Vassallo
May 16, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mayuko IchimuraKatsuhisa Omagari
Jun 23, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sarit AnaviOren Tirosh
Dec 30, 2015·Atherosclerosis·Pedro Melgar-LesmesMercedes Balcells
Feb 18, 2016·Medical Molecular Morphology·Shinichi AbeKoichi Izumikawa
May 26, 2017·International Journal of Biological Macromolecules·André L da CunhaYara M Michelacci

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
protein assay
electrophoresis
MDA
nuclear translocation

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.