Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice

Developmental Genetics
T KatagiriG Karsenty

Abstract

Analysis of the skeletal phenotypes caused by the genetic inactivation of individual Bmps, along with the study of their expression patterns, suggest possible functional redundancy of these molecules. To investigate the effect on skeleton development of the combined absence of some Bmp genes expressed in the same areas, we have intercrossed heterozygous Bmp7 mice with Bmp2 +/-, Bmp4 +/-, or Bmp5 +/- animals. Bmp2/7 and Bmp5/7 double heterozygous animals do not present with any abnormalities. In contrast, Bmp4/7 double heterozygotes develop minor defects in two restricted areas of the skeleton, the rib cage, and the distal part of the limbs. In the ribs, Bmp4 and Bmp7 seem to act in the same pathway to assure proper guidance of mesenchymal condensations of the ribs extending toward the sternum. In the limbs, these molecules appear to play a similar role in controlling digit number, possibly through induction of apoptosis in the interdigital and anterior mesenchyme.

References

Nov 12, 1965·Science·M R Urist
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T K Sampath, A H Reddi
Apr 26, 1995·Biochemical and Biophysical Research Communications·M HazamaY Fujisawa
May 25, 1995·Biochemical and Biophysical Research Communications·A AonoY Fujisawa
Jan 7, 1993·Nature·L Niswander, G R Martin
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D L GriffithW D Carlson
Mar 1, 1996·Nature Genetics·J T ThomasF P Luyten
Mar 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A T Dudley, E J Robertson
Jul 1, 1964·The British Journal of Ophthalmology·R DALGLEISH

❮ Previous
Next ❯

Citations

Jun 9, 2000·Kidney International·P Ducy, G Karsenty
Mar 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Takayuki SuzukiJohn F Fallon
Dec 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nicholas W PlummerLutz Birnbaumer
Jun 1, 2005·Molecular and Cellular Biology·Anne PizardJ G Seidman
Nov 6, 2009·Annual Review of Genetics·Barbara Conradt
May 21, 2010·Molecular Endocrinology·Michael J IsaacsSenyon Choe
Feb 26, 2010·Development·Ayako KimuraShu Takeda
Jun 7, 2007·Journal of Cell Science·Xiaohong TanXiao Yang
Sep 29, 2004·Biological Chemistry·Walter SebaldThomas D Mueller
Jul 11, 2002·Oral Diseases·T Katagiri, N Takahashi
Oct 13, 2007·The International Journal of Biochemistry & Cell Biology·X YangI Brockhausen
Oct 27, 1999·Mechanisms of Development·J Heymer, U Rüther
Jan 14, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y H WangM Mina
Mar 1, 2018·Current Osteoporosis Reports· PearlinDwaipayan Sen
May 17, 2017·Cold Spring Harbor Perspectives in Biology·Ingo GrafeYuji Mishina
Jan 6, 2001·The Journal of Experimental Zoology·J Capdevila, J C Izpisúa Belmonte
Dec 14, 2002·Genesis : the Journal of Genetics and Development·Guang-Quan Zhao
Apr 27, 2002·American Journal of Medical Genetics·M Michael Cohen
Sep 17, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Carlos I Lorda-DiezJuan M Hurle
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wei ZhuChisa Hidaka
Jun 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M HockD Stanislaus
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B C van der EerdenJ M Wit
Oct 27, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Päivi KettunenKeijo Luukko
Mar 9, 2007·American Journal of Medical Genetics. Part a·George J FeldmanEileen M Shore
Jul 11, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Juan A Montero, Juan M Hurlé
Dec 25, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·C KappenR Finnell
Apr 25, 2009·Genesis : the Journal of Genetics and Development·Takashi UchimuraYuji Mishina
Sep 26, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kunikazu TsujiVicki Rosen
Jul 31, 2007·Development, Growth & Differentiation·Benoît Robert
Feb 28, 2006·Journal of Bone and Mineral Metabolism·Fumitaka KugimiyaUng-Il Chung
Dec 6, 2002·Endocrine Reviews·Hua ChangMartin M Matzuk
Aug 13, 2003·The Journal of Biological Chemistry·Takatora TakadaRyutaro Kamijo
Jul 17, 1998·Developmental Genetics·G Karsenty
Dec 12, 2003·The Journal of Bone and Joint Surgery. American Volume·David L GlaserEileen M Shore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.