Skeletal changes in transgenic male mice expressing human cytochrome p450 aromatase

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
ZhiQi PengMatti Poutanen

Abstract

In this study, we showed that overexpressing P450 aromatase in male mice can increase bone mass and strengthen the tibia. Probably as a result of the action of products of local estrogen biosynthesis at different stages of life, the increased bone mass in young mice was induced by decreased bone turnover, but in aged animals, it was induced by increased bone formation. To understand the skeletal responses to the testosterone/estrogen balance, especially to excess estrogen produced by extragonadal biosynthesis, we investigated the bone changes in transgenic mice overexpressing human aromatase. Sixty-one young (40 days) and 25 aged (9 months) transgenic and wildtype (WT) mice were used. Bone samples were analyzed using pQCT, histomorphometry, and mechanical testing. Concentrations of testosterone (T) and estradiol (E2) were measured in serum and testicular interstitial fluid. Young P450 aromatase-positive (AROM+) mice had much higher trabecular BMD in the proximal tibia than WT mice, and the tissue area was significantly smaller in the former. Histomorphometric data further showed that the longitudinal growth rate of the tibia was decreased in AROM+ mice, and the bone formation rate (BFR) was decreased in trabecular bone and peri...Continue Reading

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Citations

Sep 4, 2009·Molecular Human Reproduction·Xiangdong Li
Feb 5, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Zhongbo LiuShoshana Yakar
Sep 3, 2008·General and Comparative Endocrinology·Xiangdong Li, Nafis Rahman
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·ZhongYi ShenMatti Poutanen
Sep 26, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yong-Jun LiuHong-Wen Deng
Sep 10, 2014·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson
Jul 17, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sofia Movérare-SkrticClaes Ohlsson
Oct 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jorma A MäättäKalervo Väänänen

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