Skeletal effects of low-dose cyclosporin A in aged male rats: lack of relationship to serum testosterone levels

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Reinhold G ErbenR Gärtner

Abstract

The aim of this study was to investigate the skeletal effects of cyclosporin A (CsA) in a dose range relevant to clinical medicine in lumbar vertebral cancellous bone of aged male rats and to correlate these effects with possible changes in serum testosterone levels. Thirty-one 18-month-old male Wistar rats were divided into four weight-matched groups and subcutaneously injected with either 0, 1, 3, or 5 mg of CsA/kg of body weight three times per week After 4 weeks of treatment, all rats were killed after in vivo fluorochrome labeling and the first lumbar vertebrae analyzed by quantitative histomorphometry. Serum was analyzed for total calcium, creatinine, alkaline phosphatase, osteocalcin, parathyroid hormone, total testosterone, and CsA levels. CsA administration resulted in a dose-dependent increase in serum osteocalcin levels and in histomorphometric indices of cancellous bone turnover in the axial skeleton. Furthermore, CsA-treated rats showed a deterioration of vertebral cancellous bone structure with increased discontinuity of the trabecular bone network due to trabecular plate perforations. Serum testosterone levels were not significantly changed by CsA treatment and were uncorrelated to all biochemical or histomorphom...Continue Reading

References

May 1, 1992·Transplantation·D L SigaletA B Thomson
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·L CavalliniG G Nussdorfer
Sep 1, 1990·Calcified Tissue International·S EpsteinF Ismail
Mar 1, 1990·Annals of Internal Medicine·B P Lukert, L G Raisz
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P OrcelM C de Vernejoul
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Dec 1, 1986·Experimental and Clinical Endocrinology·J B SchmidtJ Spona
Jan 1, 1994·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R PecesJ M Urra
Apr 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S EpsteinW S Jee
Jan 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·I KatzS Epstein
Jan 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S Epstein
Jul 1, 1996·European Journal of Clinical Investigation·D ThiébaudP Burckhardt
Feb 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R G Erben
Apr 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A R BowmanS Epstein

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Citations

Jul 2, 2010·Calcified Tissue International·Ning HanZhiyong Zhang
Nov 27, 2007·Pediatric Dermatology·Clarissa C PedreiraFergus J Cameron
Mar 19, 2016·Journal of Biomedical Materials Research. Part a·Behrooz JohariAli Samadikuchaksaraei
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·Laurie E Cohen
Oct 18, 2005·Journal of Cellular Biochemistry·Majd Zayzafoon
Dec 19, 2002·Endocrinology·Reinhold G ErbenLorenz C Hofbauer
Jul 31, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agnieszka PrytułaAnn Raes
Feb 6, 2002·Pediatric Clinics of North America·Mary B Leonard, Babette S Zemel

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