Skeletal effects of magnesium deficiency in normal, ovariectomized, and estrogen-treated rats

The Anatomical Record
R Bogoroch, L F Bélanger

Abstract

The effects of magnesium deficiency in ovariectomized and estrogen-treated rats were examined in histological sections of bones and various soft tissues. The changes observed in the femora of intact rats deprived of magnesium for three weeks were: 1. a general increase in diaphyseal thickness, 2. the presence of localized fibrous or bony-like masses in subperiosteal and metaphyseal sites, and 3. the occurrence, although rare, of endosteal hyperplasia. In ovariectomized, magniesium-deprived animals, the incidence and location of fibrous masses were similar to that in the femora of magnesium-deficient intact rats; however, no increase in diaphyseal thickness was noted. Daily injections of 25 mug estradiol caused a reduction of the frequency of skeletal hyperplasia from 80% to 20%, as well as a reduction in femoral diaphyseal thickness. Estradiol hormone administration also brought about a marked alleviation of the dermal and neural manifestations of magnesium deficiency, but, at the same time, caused an exacerbation of renal calcinosis.

Associated Clinical Trials

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Citations

Jan 1, 1980·Calcified Tissue International·J E JonesL Krook
Jul 29, 2008·Current Opinion in Nephrology and Hypertension·Gang CaoRené J M Bindels
Jul 1, 2020·Acta Physiologica·Gijs A C FrankenJeroen H F de Baaij
Feb 19, 2011·The Journal of Physical Chemistry. a·Lina WangWeisheng Liu

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