Skeletal health in patients with differentiated thyroid carcinoma.

Journal of Endocrinological Investigation
M CelliniG Mazziotti

Abstract

Osteoporosis and fractures are important comorbidities in patients with differentiated thyroid cancer (DTC), with potential negative impact on quality of life and survival. The main determinant of skeletal fragility in DTC is the thyrotropin (TSH)-suppressive therapy, which is commonly recommended to prevent disease's recurrence, especially in patients with structural incomplete response after thyroid surgery and radio-iodine therapy. TSH-suppressive therapy can stimulate bone resorption with consequent bone loss, deterioration of bone microstructure and high risk of fragility fractures. The skeletal effects of TSH-suppressive therapy may be amplified when thyroid cancer cells localize to the skeleton inducing alterations in bone remodelling, impairment of bone structure and further increase in risk of fractures. The management of skeletal fragility in DTC may be challenging, since prediction of fractures is a matter of uncertainty and data on effectiveness and safety of bone-active agents in this clinical setting are still scanty. This review deals with pathophysiological, clinical and therapeutic aspects of skeletal fragility of patients with DTC.

References

Aug 1, 1992·Endocrine Reviews·G Vassart, J E Dumont
Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C CooperL J Melton
Oct 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H N RosenS L Greenspan
Dec 1, 1996·The Journal of Clinical Endocrinology and Metabolism·B UzzanG Y Perret
Feb 5, 2002·Molecular Genetics and Metabolism·Clare B HarveyGraham R Williams
Jun 14, 2003·Annals of Internal Medicine·D C BauerUNKNOWN Study of Osteoporotic Fractures Research Group
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tarja JalavaEugene McCloskey
Oct 22, 2003·Cell·Etsuko AbeMone Zaidi
Apr 16, 2004·The New England Journal of Medicine·G David Roodman
Sep 10, 2004·Clinical Endocrinology·Elaine Murphy, Graham R Williams
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gherardo MazziottiCarlo Carella
Jul 15, 2006·Thyroid : Official Journal of the American Thyroid Association·K A HeemstraJ W A Smit
Mar 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T Kuber SampathSlobodan Vukicevic
Mar 4, 2008·Endocrine-related Cancer·M M MuresanG Weryha
Mar 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Li SunMone Zaidi
Apr 11, 2008·Thyroid : Official Journal of the American Thyroid Association·Giuseppe MartiniFurio Pacini
Jun 14, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S AdamiM Rossini
Jan 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Lily L SomwaruAnne R Cappola
May 7, 2009·Thyroid : Official Journal of the American Thyroid Association·Annalisa PanicoGiovanni Lupoli
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·J H Duncan BassettGraham R Williams
May 27, 2010·The Journal of Biological Chemistry·Liza J Raggatt, Nicola C Partridge
Jul 28, 2010·Molecular Endocrinology·W Edward VisserTheo J Visser
Nov 10, 2010·Thyroid : Official Journal of the American Thyroid Association·Yorihisa OritaYoshihide Fujimoto
Nov 26, 2010·Archives of Internal Medicine·Jennifer S LeeJohn Robbins
Feb 25, 2011·The Journal of Clinical Endocrinology and Metabolism·Thenmalar VadivelooGraham P Leese
Apr 23, 2011·Annales d'endocrinologie·G R Williams
Jul 13, 2011·Thyroid : Official Journal of the American Thyroid Association·Risheng MaTerry F Davies
May 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Azeez FarookiR Michael Tuttle
Jun 8, 2012·Clinical and Investigative Medicine. Médecine Clinique Et Experimentale·Abdulgani AbonowaraSyed A Imran
Sep 22, 2012·The Journal of Clinical Investigation·Ramkumarie BaliramTerry F Davies
Sep 29, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Avantika C WaringUNKNOWN Osteoporotic Fractures in Men (MrOS) Study
Nov 5, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·John T SchousboeSanford Baim
Dec 3, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M ClarkJ H Tobias

❮ Previous
Next ❯

Citations

Dec 5, 2020·Medical Sciences : Open Access Journal·Federico Hawkins CarranzaGuillermo Martínez Diaz-Guerra
Feb 20, 2021·Hormones : International Journal of Endocrinology and Metabolism·Flaminia CarroneGherardo Mazziotti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Musculoskeletal & Neuronal Interactions
R R Recker
Journal of Musculoskeletal & Neuronal Interactions
C H Turner
Nature Reviews. Endocrinology
Martin Schlumberger, Sophie Leboulleux
Clinics in Geriatric Medicine
Susan M Friedman, Daniel Ari Mendelson
© 2021 Meta ULC. All rights reserved