Skeletal involvement in children with Langerhans cell histiocytosis: healing, complications, and functional outcome

SICOT-J
Ahmed H K AbdelaalAhmed M El Ghoneimy

Abstract

Skeletal involvement in children with Langerhans cell histiocytosis (LCH) is a common feature of the disease. Several options for the treatment of these skeletal lesions have been reported. We describe our experience in the treatment of skeletal involvement of LCH in this retrospective case series study, entailing anatomic distribution, pattern of healing, skeletal deformities, and functional outcome of skeletal LCH. A retrospective analysis was conducted for patients diagnosed with LCH and having skeletal lesions in the period between 2007 and 2015. Out of a total of 229 cases, 191 (83.4%) had skeletal involvement. Bone healing was divided into partial and complete based on the size of lesion and cortical changes in plain radiograph. Skeletal deformities were serially measured. Time to pain control, resumption of weight bearing, and the final functional status of the patient were reviewed. The mean age at presentation was 4.4 years (3 m-14.8 y) and the mean follow-up period was 53.3 months (0.2-120.7). After screening of skeletal and extra-skeletal lesions, 59 patients (31%) had M-S (Multisystem) LCH and 132 (69%) had S-S (Single system) LCH. Unifocal bone lesions were found in 81 (42.5%) patients, and multifocal bone lesions ...Continue Reading

References

Aug 5, 2004·The Journal of Bone and Joint Surgery. American Volume·Sumeet GargJohn P Dormans
Mar 2, 2010·Cancer Treatment Reviews·Oussama AblaSheila Weitzman
May 16, 2012·Journal of Pediatric Orthopedics·Andreas F MavrogenisPietro Ruggieri
May 26, 2012·Journal of Pediatric Hematology/oncology·Anna Maria PostiniFranca Fagioli
Nov 28, 2013·Journal of Pediatric Hematology/oncology·Bo Eun KimUNKNOWN Korea Histiocytosis Working Party
Mar 5, 2014·Journal of Pediatric Orthopedics·Jessica C RiveraTravis Heare
Jul 1, 2014·Journal of Pediatric Hematology/oncology·Jorge BraierPedro Zubizarreta
Sep 21, 2017·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hiromi SasakiSetsuro Komiya

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Citations

Jun 5, 2020·Preparative Biochemistry & Biotechnology·Hanan M AhmedSalwa I Hawash
Sep 10, 2020·Revista Do Instituto De Medicina Tropical De São Paulo·Lidia YamamotoThelma Suely Okay

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Methods Mentioned

BETA
biopsy

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