Skeletal Muscle Abnormalities in Heart Failure

International Heart Journal
Shintaro KinugawaHiroyuki Tsutsui

Abstract

Exercise capacity is lowered in patients with heart failure, which limits their daily activities and also reduces their quality of life. Furthermore, lowered exercise capacity has been well demonstrated to be closely related to the severity and prognosis of heart failure. Skeletal muscle abnormalities including abnormal energy metabolism, transition of myofibers from type I to type II, mitochondrial dysfunction, reduction in muscular strength, and muscle atrophy have been shown to play a central role in lowered exercise capacity. The skeletal muscle abnormalities can be classified into the following main types: 1) low endurance due to mitochondrial dysfunction; and 2) low muscle mass and muscle strength due to imbalance of protein synthesis and degradation. The molecular mechanisms of these skeletal muscle abnormalities have been studied mainly using animal models. The current review including our recent study will focus upon the skeletal muscle abnormalities in heart failure.

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Citations

Aug 25, 2015·International Journal of Cardiology·Masashige TakahashiHiroyuki Tsutsui
Jul 9, 2016·International Journal of Cardiology·Takaaki FurihataHiroyuki Tsutsui
Oct 18, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Pieter A Leermakers, Harry R Gosker
Jan 13, 2017·European Journal of Preventive Cardiology·Nikolaos Pe KadoglouJohn Parissis
Nov 21, 2017·ESC Heart Failure·Jochen SpringerStefan D Anker
Mar 1, 2018·BioMed Research International·Tomoyasu KadoguchiShintaro Kinugawa
Jan 16, 2018·International Heart Journal·Keiichi TsuchidaHirotaka Oda
Apr 21, 2018·Frontiers in Physiology·Tomoyasu KadoguchiHiroyuki Daida
May 23, 2018·Oxidative Medicine and Cellular Longevity·Johanna ÁbrigoClaudio Cabello-Verrugio
Dec 15, 2018·ESC Heart Failure·Tsuyoshi SuzukiJochen Springer
Jul 21, 2020·International Heart Journal·Akihiro OgawaKohji Shirai
Jun 2, 2020·Frontiers in Cardiovascular Medicine·Shingo TakadaShintaro Kinugawa
Apr 11, 2020·Journal of Physical Therapy Science·Tsubasa YokoteYoshihiro Imamura
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Dec 28, 2017·International Heart Journal·Yasuhiro HoshinoMinoru Ono
Jan 24, 2020·Frontiers in Cardiovascular Medicine·Yasuhiro Maejima
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Nov 24, 2019·Geriatrics & Gerontology International·Tomoyasu KadoguchiHiroyuki Daida
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Nov 9, 2019·Heart and Vessels·Yoshimi SatoSatoaki Matoba
Oct 14, 2020·European Journal of Physical and Rehabilitation Medicine·Junichi YokotaKeisuke Matsushima
Jan 1, 2020·Biochemistry and Biophysics Reports·Satoshi MaekawaShintaro Kinugawa
Dec 11, 2020·BMC Cardiovascular Disorders·Iván José Fuentes-AbolafioAntonio Ignacio Cuesta-Vargas

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