Skeletal muscle alterations in patients with chronic heart failure

European Heart Journal
M SchaufelbergerK Swedberg

Abstract

To investigate skeletal muscle in patients with chronic heart failure and controls, and relate skeletal muscle variables to functional class, exercise capacity, central haemodynamics, muscle strength and medical treatment. Biopsy from the lateral vastus muscle was obtained in 43 patients and 20 controls. Right sided heart catheterization was performed in 19 patients and maximal exercise testing in 26 patients. In nine patients muscle strength was measured. Patients had higher lactate levels, higher lactate dehydrogenase activity, and lower oxidative enzymes activity than controls. In patients, the percentage of type I fibres and capillarization were decreased while the percentage of type II B fibres were increased. Lactate dehydrogenase activity correlated with exercise capacity, muscle strength and right atrial pressure. Digoxin-treated patients had significantly lower oxidative enzyme activity than patients without digoxin treatment. Patients with chronic heart failure have several skeletal muscle abnormalities. Central haemodynamics and medical treatment may, in addition to inactivity, be important in skeletal muscle changes.

Citations

Jun 13, 2006·Pflügers Archiv : European journal of physiology·B MettauerR Ventura-Clapier
Oct 13, 2007·Heart Failure Reviews·Randy W Braith, Darren T Beck
May 10, 2005·The American Journal of Cardiology·Randy W BraithJuan M Aranda
Jun 13, 2001·Journal of the American College of Cardiology·K K WitteJ G Cleland
Oct 14, 2003·The Lancet Oncology·Alejandro LucíaMargarita Pérez
Feb 28, 2001·Diabetes, Obesity & Metabolism·W DoehnerA J Coats
Jul 6, 2004·Journal of Cardiopulmonary Rehabilitation·Thierry TroostersMarc Decramer
Jul 29, 2006·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Wassim MoallaSaid Ahmaidi
Aug 8, 2009·Journal of Applied Physiology·Martijn A BekedamWillem J van der Laarse
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·J G PantojaM B Reid
Dec 10, 2009·Medicine and Science in Sports and Exercise·Morten MunkvikPer Kristian Lunde
Dec 4, 2012·Clinical Interventions in Aging·Michael P GodardPatrice Delafontaine
Dec 3, 2013·Current Heart Failure Reports·Georgios TzanisSerafim Nanas
Jul 1, 2014·Heart Failure Clinics·Mark J Haykowsky, Dalane W Kitzman
Apr 25, 2008·Scandinavian Journal of Urology and Nephrology·Elisabeth BrodinKatharina Stibrant Sunnerhagen
May 7, 2008·International Journal of Cardiology·Turgay CelikErsoy Isik
Mar 3, 2007·Progress in Cardiovascular Diseases·Klaus K Witte, Andrew L Clark
Sep 8, 1998·Journal of Cardiac Failure·K S SunnerhagenG Grimby
Mar 9, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F M E FranssenA M W J Schols
Nov 1, 2005·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Asa CiderKatharina Stibrant Sunnerhagen
Sep 10, 1998·Journal of Cardiovascular Pharmacology·M MetraL Dei Cas
Mar 21, 2007·American Journal of Physical Medicine & Rehabilitation·William J Evans, Charles P Lambert
Sep 2, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Bruno-Pierre DubéPierantonio Laveneziana
Sep 1, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Daniel M HiraiDavid C Poole
Mar 16, 2017·BMC Musculoskeletal Disorders·Jan L BjersingKaisa Mannerkorpi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.