Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium

Oncotarget
Hang WangChang-Jer Wu

Abstract

Chemotherapy can cause cachexia, which is manifested by weight loss, inflammation and muscle atrophy. However, the mechanisms of tumor and chemotherapy on skeletal muscle proteolysis, remained unclear. In this report, we demonstrated that tumor-induced myostatin in turn induced TNF-α, thus activating calcium-dependent and proteasomal protein degradation. Chemotherapy activated myostatin-mediated proteolysis and muscle atrophy by elevating IL-6. In tumor-bearing mice under chemotherapy, supplementation with fish oil and selenium prevented a rise in IL-6, TNF-α and myostatin and muscle atrophy. The findings presented here allow us to better understand the molecular basis of cancer cachexia and potentiate nutrition supplementation in future cancer chemotherapy.

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Citations

Nov 9, 2016·Nutrition & Metabolism·Dóra BodnárPéter Szentesi
Aug 28, 2020·Journal of Applied Genetics·Anna CiecierskaTomasz Sadkowski
Sep 16, 2017·European Journal of Preventive Cardiology·Louise G Shewan
Jun 7, 2017·Physiological Reports·Thomas ChaillouJohanna T Lanner
Jul 25, 2021·Cancers·Dean G CampeljEmma Rybalka

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Methods Mentioned

BETA
ELISA
PCR
Assay
electrophoresis

Software Mentioned

Primer3
TotalLab
Fotodyne Image analysis System
Prism Graph Pad

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