Skeletal muscle cells possess a 'memory' of acute early life TNF-α exposure: role of epigenetic adaptation

Biogerontology
Adam P SharplesClaire E Stewart

Abstract

Sufficient quantity and quality of skeletal muscle is required to maintain lifespan and healthspan into older age. The concept of skeletal muscle programming/memory has been suggested to contribute to accelerated muscle decline in the elderly in association with early life stress such as fetal malnutrition. Further, muscle cells in vitro appear to remember the in vivo environments from which they are derived (e.g. cancer, obesity, type II diabetes, physical inactivity and nutrient restriction). Tumour-necrosis factor alpha (TNF-α) is a pleiotropic cytokine that is chronically elevated in sarcopenia and cancer cachexia. Higher TNF-α levels are strongly correlated with muscle loss, reduced strength and therefore morbidity and earlier mortality. We have extensively shown that TNF-α impairs regenerative capacity in mouse and human muscle derived stem cells [Meadows et al. (J Cell Physiol 183(3):330-337, 2000); Foulstone et al. (J Cell Physiol 189(2):207-215, 2001); Foulstone et al. (Exp Cell Res 294(1):223-235, 2004); Stewart et al. (J Cell Physiol 198(2):237-247, 2004); Al-Shanti et al. (Growth factors (Chur, Switzerland) 26(2):61-73, 2008); Saini et al. (Growth factors (Chur, Switzerland) 26(5):239-253, 2008); Sharples et al. (J ...Continue Reading

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Citations

Jun 1, 2016·Biogerontology·Graeme L Close, James E Brown
Nov 29, 2016·The British Journal of Nutrition·Viviana Arroyo-JousseFrancisco Pérez-Bravo
Feb 1, 2018·Scientific Reports·Robert A SeaborneAdam P Sharples
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Feb 16, 2019·Epigenetics : Official Journal of the DNA Methylation Society·David John HunterSarabjit S Mastana
Sep 12, 2019·Journal of Cachexia, Sarcopenia and Muscle·Lingxiao HeMartine Thomis
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Aug 20, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew G FisherJonathan C Jarvis
Aug 5, 2017·Journal of Applied Physiology·Keisuke NakamuraFuminori Kawano
Aug 28, 2020·Frontiers in Physiology·Anna Prats-PuigAbel López-Bermejo
May 27, 2017·BMC Genomics·Ilhem MessaoudiOleg Varlamov
Oct 16, 2020·Journal of Cachexia, Sarcopenia and Muscle·Lingxiao HeMartine Thomis
Sep 4, 2020·Journal of Cachexia, Sarcopenia and Muscle·Kevin A MurachCory M Dungan
Apr 30, 2021·Translational Oncology·Anastasia KottorouAspasia Tsezou
Aug 17, 2021·Frontiers in Cell and Developmental Biology·Kai YouXuewen Xu

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