Skeletal muscle depletion is associated with reduced plasma (n-3) fatty acids in non-small cell lung cancer patients

The Journal of Nutrition
Rachel A MurphyVera C Mazurak

Abstract

Upwards of 50% of newly diagnosed advanced lung cancer patients have severe muscle wasting (sarcopenia). Supplementation with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in advanced cancer has been shown to attenuate lean tissue wasting. However, the relationship between muscle mass and plasma (n-3) fatty acids in the absence of supplementation is unclear. We aimed to determine how plasma phospholipid (n-3) fatty acids relate to sarcopenia and change in muscle mass in non-small cell lung cancer patients receiving chemotherapy. Computed tomography images were used to measure muscle mass. Patients were classified as sarcopenic or nonsarcopenic based on sex-specific cutpoints. Change in muscle mass during chemotherapy (2.5 mo) was calculated and patients were divided into quartiles based on the rate of muscle loss or gain. Patients with sarcopenia had lower plasma EPA (16.7 +/- 2.1 micromol/L vs. 31.6 +/- 4.4 micromol/L; P = 0.001), DHA (36.6 +/- 4.0 micromol/L vs. 55.3 +/- 4.0 micromol/L; P = 0.003), and Sigma(n-3) fatty acids (63.6 +/- 5.6 micromol/L vs. 95.0 +/- 7.7 micromol/L; P = 0.002) than nonsarcopenic patients. Patients with maximal muscle loss (mean - 3.5 kg) had lower plasma EPA (12.2 +/- 3.3 micromol/L v...Continue Reading

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Citations

Dec 14, 2011·Lipids·Rachel A MurphyVera C Mazurak
Jul 17, 2013·Current Osteoporosis Reports·Kelsey M ManganoMarian T Hannan
May 25, 2012·The British Journal of Nutrition·Mariette Gerber
May 30, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Julia B EwaschukVera C Mazurak
Aug 20, 2011·The Journal of Nutritional Biochemistry·Brian S FinlinCharlotte A Peterson
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Oct 12, 2017·Critical Reviews in Food Science and Nutrition·Marco GalloUNKNOWN NIKE Group
Aug 2, 2013·The Cochrane Database of Systematic Reviews·Vinicius CavalheriKylie Hill
Jun 18, 2019·The Cochrane Database of Systematic Reviews·Vinicius CavalheriKylie Hill
Oct 12, 2011·Current Opinion in Supportive and Palliative Care·Alisdair J MacDonaldVickie Baracos
Mar 1, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Rachel A MurphyVera C Mazurak
Jul 16, 2019·Journal of Cachexia, Sarcopenia and Muscle·Ana Anoveros-BarreraVera C Mazurak
Jan 29, 2020·Journal of Cachexia, Sarcopenia and Muscle·Amritpal S BhullarVera C Mazurak
Mar 14, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·B S van der Meij, Vera C Mazurak
Aug 31, 2016·In Vitro Cellular & Developmental Biology. Animal·Rachel A SternPaul E Mozdziak
Oct 22, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Patricia Casas-AgustenchCristina Andrés-Lacueva
Feb 18, 2016·Nutrition and Metabolic Insights·Amritpal S BhullarVera C Mazurak
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May 1, 2019·Nutrients·Raquel D S Freitas, Maria M Campos
May 13, 2020·Nutrition and Cancer·Owen M VegaSara Huerta-Yepez
Oct 25, 2020·Current Nutrition Reports·Khushboo GalaStephen A McClave

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