Skeletal muscle disease in rheumatoid arthritis: the center of cardiometabolic comorbidities?

Current Opinion in Rheumatology
Brian J Andonian, Kim M Huffman

Abstract

Despite its critical roles in body movement, structure, and metabolism, skeletal muscle remains underappreciated in the context of rheumatoid arthritis. In rheumatoid arthritis, chronic inflammation, physical inactivity, and medication toxicities impair skeletal muscle. These skeletal muscle alterations contribute to continued rheumatoid arthritis disparities in physical function and cardiometabolic health. In the prebiologic disease-modifying antirheumatic drug era, rheumatoid arthritis skeletal muscle atrophy was the central feature of 'rheumatoid cachexia,' a hypermetabolic state driven by chronic systemic inflammation and muscle protein degradation. In the current era, rheumatoid arthritis muscle deficits are less visible, yet persist as a key component of 'sarcopenic obesity.' In rheumatoid arthritis sarcopenic obesity, chronic inflammation, physical inactivity, and medication toxicities contribute to muscle contractile deficits, inflammation, altered metabolism, and intramuscular adiposity, a key predictor of rheumatoid arthritis disability and insulin resistance. Rheumatoid arthritis skeletal muscle disease in the current era is defined by impaired contractile function (poor strength and endurance) and sarcopenic obesity...Continue Reading

References

Jul 1, 1984·Arthritis and Rheumatism·J T HallaR E Schrohenloher
Nov 1, 1994·Annals of the Rheumatic Diseases·P S Helliwell, S Jackson
Jun 1, 1994·The Journal of Clinical Investigation·R RoubenoffI H Rosenberg
Jun 1, 1996·Seminars in Arthritis and Rheumatism·O MiróJ M Grau
Jul 29, 2000·Ultrastructural Pathology·L de PalmaC Bertoni-Freddari
Mar 15, 2002·The New England Journal of Medicine·Jonathan MyersJ Edwin Atwood
Aug 7, 2002·International Journal of Cardiology·Joseph Walsmith, Ronenn Roubenoff
Nov 17, 2004·Annals of Internal Medicine·Li WeiBrian R Walker
Sep 2, 2006·Arthritis and Rheumatism·Patrick H Dessein, Barry I Joffe
Feb 25, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Giorgos S MetsiosGeorge D Kitas
Jul 31, 2009·Musculoskeletal Care·Tracey E TomsGeorge D Kitas
Aug 15, 2009·Arthritis Research & Therapy·Zsuzsanna BakaGyörgy Nagy
Nov 4, 2009·Journal of Diabetes Science and Technology·Dana L DurenWm Cameron Chumlea
Sep 28, 2010·Lancet·David L ScottTom W J Huizinga
Dec 29, 2011·Case Reports in Medicine·Salaheddin SharifStephen E Alway
Jan 24, 2012·Annals of the Rheumatic Diseases·Christina Charles-SchoemanSrinivasa T Reddy
Mar 20, 2012·Annals of the Rheumatic Diseases·Juan Antonio Avina-ZubietaDiane Lacaille
Jul 19, 2012·Muscle & Nerve·Karel G M BeenakkerAndrea B Maier
Jul 27, 2012·Arthritis Care & Research·Patricia P KatzEdward H Yelin
Nov 22, 2012·Expert Review of Clinical Immunology·Beatriz Y HanaokaLeslie J Crofford
Sep 10, 2013·European Heart Journal·Nancy A Rigotti, Carole Clair
Oct 5, 2013·European Journal of Preventive Cardiology·Kasper AndersenJohan Sundström
Nov 20, 2013·Current Opinion in Rheumatology·M Kristen DemoruelleV Michael Holers
Jul 25, 2014·Annals of the Rheumatic Diseases·Bing LuElizabeth W Karlson
Nov 26, 2014·Nature Reviews. Rheumatology·Fabiana B Benatti, Bente K Pedersen
Dec 17, 2014·Current Allergy and Asthma Reports·Ayse Bag-Ozbek, Jon T Giles

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