Skeletal muscle ECF pH error signal for exercise ventilatory control

Journal of Applied Physiology
A B EvansD M Systrom

Abstract

An autonomic reflex linking exercising skeletal muscle metabolism to central ventilatory control is thought to be mediated by neural afferents having free endings that terminate in the interstitial fluid of muscle. To determine whether changes in muscle extracellular fluid pH (pHe) can provide an error signal for exercise ventilatory control, pHe was measured during electrically induced contraction by 31P-magnetic resonance spectroscopy and the chemical shift of a phosphorylated, pH-sensitive marker that distributes to the extracellular fluid (phenylphosphonic acid). Seven lightly anesthetized rats underwent unilateral continuous 5-Hz sciatic nerve stimulation in an 8.45-T nuclear magnetic resonance magnet, which resulted in a mixed lactic acidosis and respiratory alkalosis, with no net change in arterial pH. Skeletal muscle intracellular pH fell from 7.30 +/- 0.03 units at rest to 6.72 +/- 0.05 units at 2.4 min of stimulation and then rose to 7.05 +/- 0.01 units (P < 0.05), despite ongoing stimulation and muscle contraction. Despite arterial hypocapnia, pHe showed an immediate drop from its resting baseline of 7.40 +/- 0.01 to 7.16 +/- 0.04 units (P < 0.05) and remained acidic throughout the stimulation protocol. During the on...Continue Reading

References

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Citations

Feb 26, 1998·Journal of Applied Physiology·D A OelbergD M Systrom
May 5, 2006·Medicine and Science in Sports and Exercise·Ricardo Mora-Rodriguez, Roberto Aguado-Jimenez
Dec 6, 2005·European Journal of Heart Failure·Roland WenselMassimo F Piepoli
Sep 8, 2019·European Journal of Applied Physiology·Kathryn H MelamedDavid M Systrom
Nov 30, 1999·Journal of Applied Physiology·P Haouzi, A Huszczuk

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