Skeletal muscle endurance and muscle metabolism in patients with chronic heart failure.

The Canadian Journal of Cardiology
Patrice BrassardJean Jobin

Abstract

Alterations in skeletal muscle function are known to contribute to exercise intolerance in patients with chronic heart failure (CHF). To evaluate whether muscle isometric endurance can be objectively measured and whether it is related to skeletal muscle metabolism in CHF. Isometric endurance of the vastus lateralis, measured as time to fatigue (T(F)), was evaluated in 25 patients with CHF (55+/-8 years of age [mean +/- SD]) and 18 healthy subjects (HS) (62+/-6 years of age [mean +/- SD]). Median frequency of surface electromyography was obtained from spectral analysis using a fast Fourier transformation. Citrate synthase (CS), 3-hydroxyacyl-CoA dehydrogenase (HADH), hexokinase (HK) and phosphofructokinase (PFK) activities were determined from the right vastus lateralis muscle. T(F) was lower in CHF patients than in HS (49+/-4 s and 80+/-7 s, respectively; P<0.01). Muscle fatigue was present at the end of the endurance test in both groups (median frequency breakpoint at mid-exercise for both groups [P<0.05]). CS (P<0.01) and HK (P<0.01) activities were lower in CHF patients than in HS, but PFK activity was higher (P<0.05). T(F) correlated significantly with CS (r=0.50), HADH (r=0.42), PFK (r=-0.47) and HK (r=0.41) activities and...Continue Reading

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Citations

Feb 15, 2016·The Canadian Journal of Cardiology·Patrice Brassard, Finn Gustafsson
May 23, 2008·American Journal of Physical Medicine & Rehabilitation·Gaëll DeleyJean-Marie Casillas
Dec 10, 2009·Medicine and Science in Sports and Exercise·Morten MunkvikPer Kristian Lunde
Jul 22, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Olga TheouAnthony A Vandervoort
Dec 12, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Damien M Callahan, Michael J Toth
Jul 19, 2014·Current Opinion in Cardiology·Ross ArenaShane A Phillips
Jan 17, 2017·Heart Failure Reviews·Danielle L BrunjesP Christian Schulze
Mar 9, 2019·Frontiers in Physiology·Manda L Keller-RossBruce D Johnson

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