Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.

The Journal of Physiological Sciences : JPS
David L AllenSarah F Lindsay

Abstract

Members of the bone morphogenetic protein-1/mammalian tolloid (BMP-1/mTLD) family of proteases cleave diverse extracellular proteins, including the growth inhibitor myostatin. The purpose of this work was to examine the expression of BMP-1/mTLD, tolloid-like-1 and -2 (TLL1 and TLL2) in hindlimb muscles of the mouse in vivo and in C(2)C(12) muscle cells in vitro. Quantitative real-time polymerase chain reaction revealed that neither BMP-1/mTLD nor TLL1 mRNA levels differed between the predominantly fast-twitch tibialis anterior (TA) and gastrocnemius (GAST) muscles and the more slow-twitch soleus (SOL) muscle; TLL2 mRNA levels were not detectable in any of the muscles examined. Interestingly, however, immunohistochemical analysis revealed that BMP-1 protein was expressed in type I and IIa but not in IIb fibers. TLL1 mRNA levels significantly increased in the TA but not the SOL with 3 days of hindlimb suspension and significantly decreased in both TA and SOL in response to 2 days of food deprivation. In contrast, BMP-1/mTLD mRNA levels were unaffected in either muscle by either condition. In addition, BMP-1/mTLD and TLL1 mRNA levels significantly decreased during C(2)C(12) myoblast differentiation in vitro, and activity of a 1,20...Continue Reading

References

Jan 1, 1993·Molecular Aspects of Medicine·B KaltschmidtC Kaltschmidt
Aug 1, 1997·The American Journal of Physiology·D L AllenV R Edgerton
Feb 13, 2001·Biochemical and Biophysical Research Communications·R RíosJ Devesa
Feb 24, 2001·Journal of Muscle Research and Cell Motility·L MendlerF Wuytack
Nov 10, 2001·American Journal of Physiology. Endocrinology and Metabolism·K MaS Bhasin
Dec 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Neil M WolfmanSe-Jin Lee
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stewart H LeckerAlfred L Goldberg
Jun 11, 2004·American Journal of Physiology. Cell Physiology·Mônica Senna SalernoMridula Sharma
Nov 9, 2005·Brain Research. Molecular Brain Research·Goichiro TamuraTimothy G Clark
Apr 20, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Gaoxiang Ge, Daniel S Greenspan
Aug 4, 2006·American Journal of Physiology. Cell Physiology·David L Allen, Terry G Unterman
Nov 23, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jennifer M SacheckAlfred L Goldberg
Jun 15, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·Delana R HopkinsDaniel S Greenspan
Mar 13, 2008·American Journal of Physiology. Endocrinology and Metabolism·David L AllenRyan S Mehan
Dec 17, 2008·Journal of Applied Physiology·David L AllenJeremy L Barth

❮ Previous
Next ❯

Citations

Nov 21, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jafar SharifHaruhiko Koseki
Mar 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Astrid BreitbartJoerg Heineke
Jun 16, 2011·Biochemical and Biophysical Research Communications·Akiko OndaToru Fukubayashi
Mar 15, 2011·American Journal of Obstetrics and Gynecology·Maria A T BortoliniMay Alarab
Jun 13, 2015·Oxidative Medicine and Cellular Longevity·Joo Wan KimYung Hyun Choi
Apr 1, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Thomas Bernd Dschietzig
Jul 5, 2013·BMC Research Notes·Melanie J HayesJane A Taylor
Nov 2, 2014·BMC Musculoskeletal Disorders·Patience N Erick, Derek R Smith
Apr 12, 2016·Ergonomics·Nicholas J La DelfaSamuel J Howarth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved