Skeletal muscle fat deposition is associated with hepatocellular carcinoma development in patients with chronic liver disease

Nutrition
Yoshihiko TachiHidemi Goto

Abstract

The effect of skeletal muscle fat deposition on the prognosis of patients with chronic liver disease remains unclear. Skeletal muscle fat deposition can be estimated by attenuation of skeletal muscle in Hounsfield units (HU) on computed tomography (CT). The aim of this retrospective cohort study was to investigate the association between skeletal muscle fat deposition assessed by skeletal muscle attenuation (SMA), and hepatocellular carcinoma (HCC). We enrolled 288 patients with chronic liver disease (139 men, 149 women; mean age 67.5 ± 10.4 y; hepatitis C virus, 239; hepatitis B virus, 17; without viral infection, 32; chronic hepatitis, 227; and cirrhosis, 61) who underwent liver biopsy and CT scanning between January 2013 and February 2017. The patients were divided into two groups based on SMA levels, with the cutoff value of 31 HU. We analyzed the effect of SMA on HCC development. During the study follow-up period (median, 2.50 y; range, 0.5-4.7 y), HCC was identified in 19 patients (7%). The cumulative incidence of HCC in patients with lower SMA (<31 HU) was significantly higher than in patients with SMA ≥31 HU (P = 0.007). Cox proportional hazards regression analysis confirmed cirrhosis (hazard ratio [HR], 6.626; 95% conf...Continue Reading

Citations

Mar 21, 2020·Clinical Physiology and Functional Imaging·Taiara Scopel PoltronieriGabriela Villaça Chaves
Nov 17, 2020·Expert Review of Gastroenterology & Hepatology·Giovanni MarascoMatteo Renzulli
Feb 15, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Zhichao FengWei Wang

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