PMID: 9420659Sep 1, 1995Paper

Skeletal muscle fiber composition and capillarization in patients with chronic heart failure: relation to exercise capacity and central hemodynamics

Journal of Cardiac Failure
M SchaufelbergerK Swedberg

Abstract

Patients with chronic heart failure have structural and metabolic changes in skeletal muscle, which may be of importance for symptomatology. The origin of these changes are still unknown. The relationship between fiber composition and capillarization in skeletal muscle with exercise capacity and central hemodynamic variables was examined. Biopsies from the lateral vastus muscle were taken in 12 patients with chronic heart failure. Samples from eight normal subjects served as control samples. All patients underwent maximal exercise tests. Central hemodynamic variables were measured during exercise in five patients. The patients had a higher percentage of type II B fibers (P = .03) and fewer capillaries per fiber (P = .02) than the controls subjects. VO2 max correlated with the percentage of type I fibers, whereas the correlation with the type II A fibers was inverse. Cardiac index and pulmonary capillary wedge pressure at submaximal and maximal exercise were related to fiber type composition and relative fiber areas. Skeletal muscle fiber type composition and capillarization was changed in patients with chronic heart failure. These changes might influence exercise capacity. There were relationships between central hemodynamic va...Continue Reading

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Citations

Jun 5, 2003·Journal of Cardiopulmonary Rehabilitation·Ross ArenaMichael Madigan
Oct 16, 2012·Heart Failure Reviews·Cynthia Zizola, P Christian Schulze
Sep 30, 2010·Scandinavian Journal of Medicine & Science in Sports·G SlettaløkkenJ Hallén
Jul 25, 2015·Annals of the New York Academy of Sciences·Miranda M Sung, Jason R B Dyck
Mar 9, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F M E FranssenA M W J Schols
Jun 9, 2016·Current Heart Failure Reports·Andrew R Coggan, Linda R Peterson
Nov 1, 2005·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Asa CiderKatharina Stibrant Sunnerhagen
Sep 25, 2017·Current Heart Failure Reports·Volker AdamsEphraim Winzer
Feb 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Carlos E NegraoLigia M Antunes-Correa
Dec 22, 2019·Journal of Cachexia, Sarcopenia and Muscle·Jack O GarnhamKlaus K Witte
Nov 30, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Rogerio N SoaresJuan M Murias
Sep 1, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Daniel M HiraiDavid C Poole
Jan 18, 2020·Nutrients·Francesco CurcioPasquale Abete
Jan 9, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Roger W P KissaneStuart Egginton
Jun 30, 2021·Current Cardiology Reports·Sara RovaiPiergiuseppe Agostoni

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