Skeletal muscle glucose transporter protein responses to antenatal glucocorticoids in the ovine fetus

The Journal of Endocrinology
Susan GrayS U Devaskar

Abstract

We investigated the effects of maternal antenatal dexamethasone (Dex) treatment given as a single course (4 doses) or multiple courses (20 doses) on fetal skeletal muscle glucose transporter (GLUT) protein concentrations at 70% of gestation (106 to 107 days with term being 145 to 150 days) in the ovine fetus. Antenatal corticosteroid administration was associated with a decrease in endogenous fetal plasma cortisol concentrations (P < 0.05), fetal hyperglycemia (P < 0.02) and hyperinsulinemia (P < 0.05). These metabolic/hormonal changes were associated with a decrease in fetal body weight (P < 0.05) in the multiple course Dex group compared with the multiple course placebo group. These perturbations were associated with an increase in fetal skeletal muscle GLUT 1 concentrations that mediate basal glucose transport in the extensor digitorum lateralis and extensor digitorum longus muscles (P < 0.05) 18 h after the last dose of Dex was given in the single course group. However, in the multiple course Dex group, a small increase in GLUT 1 was observed only in the biceps femoris. In contrast, both single and multiple courses of antenatal Dex were associated with an increase in the extensor digitorum lateralis and biceps femoris muscl...Continue Reading

Citations

Aug 20, 2009·American Journal of Physiology. Endocrinology and Metabolism·Anthony CarruthersSherin U Devaskar
Mar 1, 2014·The Journal of Endocrinology·Satoko HaenoHiroshi Yokota
Apr 24, 2014·The Journal of Endocrinology·Cynthia L BlancoNicolas Musi
Jul 25, 2013·Health Promotion International·Jo Pike, Soula Ioannou
Mar 31, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G Angela MassmannJorge P Figueroa
Mar 3, 2009·Experimental Physiology·Abigail L Fowden, Alison J Forhead
Feb 12, 2020·Peptides·Jorge Berlanga-AcostaRaymond J Playford

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