Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy

Metabolism: Clinical and Experimental
B L NyombaC Bogardus

Abstract

Sulfonylureas are used in the treatment of non-insulin-dependent diabetes mellitus (NIDDM) largely because of their ability to enhance insulin secretion and possibly to potentiate insulin action. In this study, we investigated the effects of chronic glyburide treatment on glycogen synthase activity determined in skeletal muscle biopsies taken during euglycemic hyperinsulinemic clamps in nine Pima Indians with NIDDM. Insulin was infused at the rate of 40 mU/m2/min (low dose) followed by 400 mU/m2/min (high dose). Compared with the fasting value, the mean glycogen synthase activity assayed at low glucose-6-phosphate (G6P) concentration (active glycogen synthase) showed no significant changes during insulin infusion before glyburide treatment. After glyburide treatment, the mean active glycogen synthase increased by 39% (P less than .05) above the fasting value during the high-dose insulin infusion. Total glycogen synthase activity assayed at high G6P concentration did not change after glyburide treatment. Changes of insulin-stimulated active glycogen synthase associated with glyburide treatment correlated with changes in total body glucose disposal rates (r = .70, P less than .05) during euglycemic clamps. We conclude that glybur...Continue Reading

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Citations

Jun 10, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mandeep Bajaj, Ralph A Defronzo
May 7, 2010·Journal of Biomedicine & Biotechnology·Muhammad A Abdul-Ghani, Ralph A DeFronzo
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Aug 17, 2004·The Medical Clinics of North America·Ralph A DeFronzo
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Nov 24, 2018·Diabetes/metabolism Research and Reviews·Evangelia KalaitzoglouKathryn M Thrailkill
Jul 1, 1997·Cambridge Quarterly of Healthcare Ethics : CQ : the International Journal of Healthcare Ethics Committees·T May
Jan 1, 1992·Journal of Endocrinological Investigation·E BonoraM Muggeo

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