Skeletal muscle-gut axis: emerging mechanisms of sarcopenia for intestinal and extra intestinal diseases

Minerva gastroenterologica e dietologica
Roberto de SireFranco Scaldaferri

Abstract

In recent years, there has been an increasing interest on muscle wasting, considering the reduction of quality of life and the increase of morbidity and mortality associated. Sarcopenia and cachexia represent two conditions of reduction of muscle mass, sharing several elements involved in their pathogenesis, such as systemic inflammation, impaired muscle protein synthesis, increased muscle apoptosis, mitochondrial dysfunction in skeletal muscle tissue and insulin resistance. These features often characterize cancer, inactivity or denervation, but also inflammatory diseases, such as chronic obstructive pulmonary disease, renal failure, cardiac failure, rheumatoid arthritis, inflammatory bowel disease and aging in general. The gastrointestinal tract and gut microbiota are thought to be deeply associated with muscle function and metabolism, although the exact mechanisms that link gut with skeletal muscle are still not well known. This review summarized the potential pathways linking gut with muscle, in particular in conditions as sarcopenia and cachexia. The main emerging pathways implicated in the skeletal muscle-gut axis are: the myostatin/activin signaling pathway, the IGF1/PI3K/AKT/mTOR signaling pathway, which results suppres...Continue Reading

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Citations

Jul 7, 2020·Journal of Cellular and Molecular Medicine·Luise EhlersRobert Jaster
Oct 2, 2020·Minerva endocrinologica·Sandro La VigneraAntonio Aversa
Apr 4, 2020·The Journal of Nutrition, Health & Aging·K BargerM S Lustgarten
May 29, 2020·Clinical and Translational Gastroenterology·Lourdes Ortiz-AlvarezBorja Martinez-Tellez
Oct 12, 2019·Minerva gastroenterologica e dietologica·Rinaldo Pellicano
Dec 31, 2020·Critical Reviews in Food Science and Nutrition·Zongxin LingShaochang Wu
Jul 7, 2020·Minerva gastroenterologica e dietologica·Umberto AimassoAndrea Devecchi
Feb 11, 2021·Nutrients·Julia TraubVanessa Stadlbauer
Feb 4, 2021·European Journal of Clinical Nutrition·Gurasis BoparaiVineet Ahuja
Nov 4, 2020·International Journal of Molecular Sciences·Ravikumar ManickamWalter Wahli
Mar 7, 2021·Nutrients·Matthew D WatsonGregory J Grosicki
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Apr 22, 2021·International Journal of General Medicine·Jiaxi ZhaoXiaofeng Yu
Jul 9, 2021·Frontiers in Nutrition·Elena de Marco CastroHelen M Roche

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