Skeletal Muscle Inflammation Following Repeated Bouts of Lengthening Contractions in Humans

Frontiers in Physiology
Michael R DeyhleRobert D Hyldahl

Abstract

Skeletal muscle responds to exercise-induced damage by orchestrating an adaptive process that protects the muscle from damage by subsequent bouts of exercise, a phenomenon called the repeated bout effect (RBE). The mechanisms underlying the RBE are not understood. We hypothesized that an attenuated inflammation response following a repeated bout of lengthening contractions (LC) would be coincidental with a RBE, suggesting a potential relationship. Fourteen men (n = 7) and women (n = 7) completed two bouts of lengthening contractions (LC) separated by 28 days. Muscle biopsies were taken before the first bout (B1) from the non-exercised leg, and from the exercised leg 2- and 27-d post-B1 and 2-d following the second bout (B2). A 29-plex cytokine array identified alterations in inflammatory cytokines. Immunohistochemistry quantified inflammatory cell infiltration and major histocompatibility complex class 1 (MHC-1). Muscle soreness was attenuated in the days following B2 relative to B1, indicating a RBE. Intramuscular monocyte chemoattractant protein (MCP1) and interferon gamma-induced protein 10 (IP10) increased following B2 relative to the pre-exercise sample (7-52 and 11-36 pg/ml, respectively p < 0.05). Interleukin 4 (IL4) dec...Continue Reading

References

Sep 1, 1995·Medicine and Science in Sports and Exercise·K Nosaka, P M Clarkson
Feb 13, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M J SpencerJ G Tidball
Aug 31, 2001·Medicine and Science in Sports and Exercise·K NosakaP Sacco
Sep 25, 2001·Journal of Applied Physiology·N StupkaS M Phillips
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer H DufourAndrew D Luster
Apr 19, 2002·Journal of Applied Physiology·Francis X PizzaSusan V Brooks
Nov 1, 2002·American Journal of Physical Medicine & Rehabilitation·Priscilla M Clarkson, Monica J Hubal
Jul 17, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Timothy J KohSusan V Brooks
Aug 2, 2003·British Journal of Sports Medicine·H Toumi, T M Best
Jul 1, 1963·The American Journal of Physiology·B HIGHMAN, P D ALTLAND
Apr 13, 2004·American Journal of Physiology. Cell Physiology·Gordon L WarrenPetia P Simeonova
Jun 7, 2005·Acta Neuropathologica·Boel De PaepeJan L De Bleecker
Dec 1, 2006·Journal of Leukocyte Biology·Paula K ShiremanLinda M McManus
Aug 21, 2007·Journal of Science and Medicine in Sport·Andrew P Lavender, Kazunori Nosaka
Mar 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Monica J HubalPriscilla M Clarkson
Sep 20, 2008·Journal of Applied Physiology·Abigail L MackeyS Peter Magnusson
Dec 2, 2009·Journal of Korean Medical Science·Jae-Hwan ChoiDae-Seong Kim
Aug 21, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Renato BarrosoValmor Tricoli
Feb 19, 2011·Journal of Applied Physiology·Makii MuthalibKazunori Nosaka
Mar 4, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Abigail L MackeyHenning Langberg
Dec 20, 2011·European Journal of Cell Biology·Clara CrescioliLuigi Di Luigi
Apr 3, 2012·Experimental Cell Research·Andrea FariniYvan Torrente
May 14, 2014·Physiological Reports·Ruud Van ThienenPeter Hespel
Oct 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing ZhangJie Du
Oct 25, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Juan WangYong Jiang
Mar 27, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Robert D HyldahlAllen C Parcell
Mar 27, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wing Yin LauKazunori Nosaka
Jun 5, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I M KhanC M Ballantyne

❮ Previous
Next ❯

Citations

Mar 11, 2017·Frontiers in Physiology·Michael O Harris-LoveBrian M Hoover
Oct 27, 2016·Exercise and Sport Sciences Reviews·Robert D HyldahlKazunori Nosaka
Oct 28, 2017·Medicine and Science in Sports and Exercise·Trevor C ChenKazunori Nosaka
May 24, 2018·Scandinavian Journal of Medicine & Science in Sports·P A PincheiraG A Lichtwark
Jan 4, 2019·Journal of Applied Physiology·Kyoungrae KimBruno T Roseguini
Jun 19, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jacob R SorensenRobert D Hyldahl
Dec 31, 2016·Journal of Applied Physiology·Jonathan M PeakeKazunori Nosaka
Jul 6, 2018·Frontiers in Physiology·Michael R Deyhle, Robert D Hyldahl
Sep 29, 2020·Frontiers in Physiology·Brandon N VanderVeenJames A Carson
Sep 16, 2017·Journal of Physiology and Biochemistry·Johanna K IhalainenAntti A Mero
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Luiz Alexandre Medrado de BarcellosVanessa Pinho
Apr 4, 2021·International Journal of Molecular Sciences·Natalia ZiemkiewiczKoyal Garg
Apr 21, 2021·European Journal of Applied Physiology·Susan Y Kwiecien, Malachy P McHugh
Jun 3, 2021·International Journal of Environmental Research and Public Health·Wélia Yasmin Horacio Dos SantosWalderi Monteiro da Silva Júnior
Jun 8, 2021·Journal of Sport and Health Science·Arash KhassetarashGuillaume Y Millet
Feb 16, 2021·The Journal of Sports Medicine and Physical Fitness·Alejandra Arroyo-CerezoMaría-Soledad Fernández-Pachón
Nov 18, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·André Luis Araujo Minari, Ronaldo V Thomatieli-Santos

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
total

Software Mentioned

Prism Graphpad
JMP® Pro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.