Skeletal muscle lactate accumulation and creatine phosphate depletion during heavy exercise in congestive heart failure. Cause of limited exercise capacity?

European Heart Journal
H NäveriM Härkönen

Abstract

To study the mechanisms of limited exercise capacity and skeletal muscle energy production in male patients with congestive heart failure. Muscle biopsy study. Skeletal muscle metabolic response to maximal bicycle exercise was studied in 10 patients with chronic congestive heart failure (ejection fraction 0.22 +/- 0.05; peak oxygen consumption, VO2 15.1 +/- 4.9 ml.min-1.kg-1) and in nine healthy subjects (peak VO2 33.5 +/- 6.7 ml.min-1.kg-1). Activities of skeletal muscle enzymes were measured from the vastus lateralis muscle of 48 patients (ejection fraction 0.24 +/- 0.06, peak VO2 17.4 +/- 5.4 ml.min-1.kg-1) and 36 healthy subjects (peak VO2 38.3 +/- 8.4 ml.min-1.kg-1). Although blood lactate levels were lower in patients than in healthy subjects (2.2 +/- 0.3 vs 5.2 +/- 0.6 mmol.l-1; P < 0.001) at peak exercise (96 +/- 11 W for patients and 273 +/- 14 W for controls), skeletal muscle lactate was similarly elevated (25.6 +/- 3.2 vs 22.7 +/- 2.7 mmol.kg-1) and creatine phosphate was equally depressed (P < 0.02) to low levels (7.0 +/- 1.9 vs 6.7 +/- 0.9 mmol.kg-1). The muscle ATP decreased by 21% (P < 0.05) and 8% (P < 0.01) in the patients and controls, respectively. Activities of rate limiting enzymes of the citric acid cycle ...Continue Reading

Citations

Feb 3, 2012·Advances in Therapy·Ettore StrumiaGiuseppe D'Ambrosio
Apr 1, 2000·European Journal of Heart Failure·K KiilavuoriM Härkönen
Dec 21, 2013·International Urology and Nephrology·Umut VarolMustafa Cirit
Dec 6, 2005·European Journal of Heart Failure·Roland WenselMassimo F Piepoli
Jun 20, 2001·Acta Physiologica Scandinavica·M F PiepoliA J Coats
Nov 19, 2011·Chronic Respiratory Disease·Rachael A Evans
Oct 19, 2017·NeuroRehabilitation·Kathrin SchlüterKarl-Heinz Schulz
Jan 23, 2003·Circulation·Adam C ScottMassimo F Piepoli
Dec 1, 2004·Medicine and Science in Sports and Exercise·Rochus PokanNorbert Bachl
Oct 30, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickUNKNOWN American Association of Clinical Endocrinologists
Dec 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Y HellstenJ Bangsbo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.