PMID: 3745039Aug 1, 1986Paper

Skeletal muscle lactate dehydrogenase isozyme alterations in men and women marathon runners

Journal of Applied Physiology
F S Apple, M A Rogers

Abstract

Total lactate dehydrogenase (LD) and LD isozyme activities in gastrocnemius muscle from trained men and women runners were measured in response to the chronic stress of training for a marathon race (42.2 km). Following 9 wk of training, total LD activity in skeletal muscle from men and women runners significantly (P less than 0.02) decreased 2.26 and 2.25 U/mg protein, respectively. However, men's total LD activities were significantly (P less than 0.001) less than the women's both before and after training. Significant (P less than 0.05) increases in LD1 activities in skeletal muscle in men and women runners were also observed after training. No significant correlations were detected between percent fiber type composition in men or women vs. the changes in total LD activity, changes in LD1 activity, maximal O2 consumption or training distance averaged per week after the training period. The biochemical adaptations in skeletal muscle that occurred in the LD isozyme composition in both men and women runners make the runners skeletal muscle appear similar to heart muscle in LD1 and LD2 activities.

Citations

Nov 1, 1990·Acta Physiologica Scandinavica·J CadefauA Urbano-Márquez
Apr 12, 2000·Acta Physiologica Scandinavica·G Van Hall
Oct 16, 2016·The Journal of Biological Chemistry·Xijun LiangZhenji Gan
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·A D Taylor, R Bronks
Jan 21, 2006·Journal of Applied Genetics·Andrzej DybusMagdalena Muszyńska
Jan 1, 1989·Veterinary Research Communications·F DoizéL DeRoth
May 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Serge SummermatterChristoph Handschin
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